Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors

机译：核苷转运蛋白和人类有机阳离子转运蛋白1决定了DNA-甲基转移酶抑制剂的细胞处理

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BACKGROUND AND PURPOSEInhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim of this study was to identify transporter proteins contributing to DNMT inhibitor action.

机译：背景和目的DNA甲基转移酶（DNMT）的抑制剂，例如氮杂胞苷，地西他滨和zebularine，用于癌症的表观遗传治疗。它们的作用可能取决于它们跨质膜的转运。这项研究的目的是鉴定有助于DNMT抑制剂作用的转运蛋白。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
C Arimany-Nardi; E Errasti-Murugarren; G Minuesa; J Martinez-Picado; V Gorboulev; H Koepsell; M Pastor-Anglada;
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作者单位

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年(卷),期 2014(171),16
年度 2014
页码 3868–3880
总页数 13
原文格式 PDF
正文语种
中图分类药学;
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专利

1. Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4) [J] . WangC., LinW., PlayaH., Biochemical Pharmacology . 2013,第11期

机译：双嘧达莫类似物作为平衡核苷转运蛋白的药理抑制剂。鉴定新型有效和选择性的人平衡核苷转运蛋白4（hENT4）的腺苷转运蛋白抑制剂
2. Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1. [J] . Damaraju VL, Smith KM, Mowles D, Biochemical Pharmacology . 2011,第1期

机译：融合的嘧啶核苷类似物与人类浓缩核苷转运蛋白的相互作用：人类浓缩核苷转运蛋白的高亲和力抑制剂1。
3. Transport of lamivudine ((-)-beta-L-2',3'-dideoxy-3'-thiacytidine) and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. [J] . Minuesa G, Volk C, Molina-Arcas M, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2009,第1期

机译：拉米夫定（（-）-beta-L-2'，3'-dideoxy-3'-thyacytidine）的转运以及核苷逆转录酶抑制剂与人类有机阳离子转运蛋白1、2和3的高亲和力相互作用。
4. Cloning and Functional Characterization of a Novel Human pH-Dependent Organic Cation Transporter, OCTN1 [C] . I. Tamai, H. Yabuuchi, J. Nezu, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：新型人类pH依赖性有机阳离子转运蛋白OCTN1的克隆和功能表征
5. Renal proximal tubular handling of nucleosides by human nucleoside transporter proteins. [D] . Elwi, Adam Nader. 2009

机译：肾近端肾小管通过人核苷转运蛋白处理核苷。
6. Dipyridamole analogues as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4) [O] . Chunmei Wang, Wenwei Lin, Hilaire Playa, -1

机译：双嘧达莫类似物作为平衡核苷转运蛋白的药理抑制剂。鉴定新型有效和选择性的人平衡核苷转运蛋白4（hENT4）的腺苷转运蛋白功能抑制剂
7. Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors [O] . Arimany Nardi, C., Errasti-Murugarren, E., Minuesa, G., 2014

机译：核苷转运蛋白和人类有机阳离子转运蛋白1决定了DNA-甲基转移酶抑制剂的细胞处理

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors

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