• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>British Medical Journal >Cigarette smoking tar yields and non-fatal myocardial infarction: 14000 cases and 32000 controls in the United Kingdom. The International Studies of Infarct Survival (ISIS) Collaborators.
【2h】

Cigarette smoking tar yields and non-fatal myocardial infarction: 14000 cases and 32000 controls in the United Kingdom. The International Studies of Infarct Survival (ISIS) Collaborators.

机译：抽烟产生焦油和非致命性心肌梗塞：英国有14000例病例和32000例对照。国际梗塞生存研究（ISIS）合作者。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES--To assess the effects of cigarette smoking on the incidence of non-fatal myocardial infarction, and to compare tar in different types of manufactured cigarettes. METHODS--In the early 1990s responses to a postal questionnaire were obtained from 13,926 survivors of myocardial infarction (cases) recently discharged from hospitals in the United Kingdom and 32,389 of their relatives (controls). Blood had been obtained from cases soon after admission for the index myocardial infarction and was also sought from the controls. 4923 cases and 6880 controls were current smokers of manufactured cigarettes with known tar yields. Almost all tar yields were 7-9 or 12-15 mg/cigarette (mean 7.5 mg for low tar (< 10 mg) and 13.3 for medium tar (> or = 10 mg). The cited risk ratios were standardised for age and sex and compared myocardial infarction rates in current cigarette smokers with those in non-smokers who had not smoked cigarettes regularly in the past 10 years. RESULTS--At ages 30-49 the rates of myocardial infarction in smokers were about five times those in non-smokers (as defined); at ages 50-59 they were three times those in non-smokers, and even at ages 60-79 they were twice as great as in non-smokers (risk ratio 6.3, 4.7, 3.1, 2.5, and 1.9 at 30-39, 40-49, 50-59, 60-69, 70-79 respectively; each 2P < 0.00001). After standardisation for age, sex, and amount smoked, the rate of non-fatal myocardial infarction was 10.4% (SD 5.4) higher in medium tar than in low tar cigarette smokers (2P = 0.06). This percentage was not significantly greater at ages 30-59 (16.6% (7.1)) than at 60-79 (1.0% (8.5)). In both age ranges the difference in risk between cigarette smokers and non-smokers was much larger than the difference between one type of cigarette and another (risk ratio 3.39 and 3.95 at ages 30-59 for smokers of similar numbers of low and of medium tar cigarettes, and risk ratio 2.35 and 2.37 at ages 60-79). Most possible confounding factors that could be tested for were similar in low and medium tar users, with no significant differences in blood lipid or albumin concentrations. CONCLUSION--The present study indicates that the imminent change of tar yields in the European Union to comply with an upper limit of 12 mg/cigarette will not increase (and may somewhat decrease) the incidence of myocardial infarction, unless they indirectly help perpetuate tobacco use. Even low tar cigarettes still greatly increase rates of myocardial infarction, however, especially among people in their 30s, 40s, and 50s, and far more risk is avoided by not smoking than by changing from one type of cigarette to another.
机译：目的-评估吸烟对非致命性心肌梗塞发生率的影响，并比较不同类型的人造香烟中的焦油含量。方法-在1990年代初，从英国医院最近出院的13926名心肌梗死幸存者（病例）及其亲属（对照）中的32389人获得了对邮政调查表的答复。入院后不久就从索引性心肌梗死病例中获得了血液，也从对照组中寻求血液。当前有4923例病例和6880例对照是吸烟者生产的焦油产量已知的人造香烟。几乎所有焦油产量为7-9或12-15 mg /支香烟（低焦油（<10 mg）平均7.5 mg，中焦油（>或= 10 mg）平均13.3）。并比较了当前吸烟者和过去10年内没有定期吸烟的非吸烟者的心肌梗塞率。结果-在30-49岁之间，吸烟者的心肌梗塞率约为非吸烟者的5倍。吸烟者（按定义）；在50-59岁时，他们是非吸烟者的三倍，甚至在60-79岁时，他们也比非吸烟者大两倍（风险比6.3、4.7、3.1、2.5和分别在30-39、40-49、50-59、60-69、70-79时为1.9；每2P <0.00001）。在对年龄，性别和吸烟量进行标准化后，非致命性心肌梗塞的发生率为10.4中等焦油含量的人（SD 5.4）比低焦油量香烟的吸烟者高（2P = 0.06），这一百分比在30-59岁年龄段（16.6％（7.1））并不明显高于60-79岁年龄段（1.0％（8.5）） ）。 ge范围表明，吸烟者与不吸烟者之间的风险差异远大于一种类型的香烟与另一种类型的香烟之间的差异（30-59岁年龄段的中低焦油量香烟数量相似的吸烟者的风险比分别为3.39和3.95，和60-79岁年龄段的风险比分别为2.35和2.37）。在中低焦油使用者中，可以测试的大多数可能混杂因素相似，血脂或白蛋白浓度无明显差异。结论-本研究表明，欧盟将要满足12毫克/支香烟上限的焦油产量的近期变化不会增加（并且可能会有所减少）心肌梗塞的发生率，除非它们间接帮助使烟草永存采用。但是，即使焦油含量低的香烟也仍然会大大增加心肌梗塞的发生率，尤其是在30多岁，40多岁和50多岁的人群中，与不从一种类型的香烟换成另一种类型的香烟相比，避免吸烟的风险要大得多。

著录项

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号