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首页> 美国卫生研究院文献>British Medical Journal >Sodium-lithium countertransport activity in red cells of patients with insulin dependent diabetes and nephropathy and their parents.
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Sodium-lithium countertransport activity in red cells of patients with insulin dependent diabetes and nephropathy and their parents.

机译：胰岛素依赖型糖尿病和肾病患者及其父母的红细胞中钠锂逆转运活性。

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OBJECTIVE--To determine whether there are familial and genetic aspects of sodium-lithium countertransport activity in red cells in diabetic nephropathy. DESIGN--Case-control study. SETTING--Teaching hospital diabetic clinic. SUBJECTS--40 Patients with insulin dependent diabetes, both of whose parents were alive: 20 with persistent proteinuria and 20 with normal albumin excretion matched for age, duration of diabetes, and body mass index. All 80 parents. MAIN OUTCOME MEASURES--Sodium-lithium countertransport activity in red cells and arterial blood pressure. RESULTS--Sodium-lithium countertransport activity in red cells was higher in the patients with proteinuria than in the patients with normoalbuminuria (mean (95% confidence interval) 0.47 (0.39 to 0.54) v 0.33 (0.28 to 0.38) mmol/l red cells/h respectively, p = 0.0036; mean difference 0.14 (0.04 to 0.22)). The mean countertransport activity for the two parents of each patient was calculated, and from this the mean value for each group of parents was calculated; the value was higher in the parents of the patients with proteinuria than in the parents of the patients with normoalbuminuria (0.40 (0.32 to 0.48) v 0.30 (0.26 to 0.33) mmol/l red cells/h respectively, p = 0.016; 0.10 (0.02 to 0.19)). Twenty-eight of the parents of the patients with proteinuria compared with 12 of the parents of the patients with normoalbuminuria had a countertransport activity that was above the median value in all 80 parents (p less than 0.001). Mean arterial blood pressure in the parents of the patients with proteinuria was related to that of their offspring (r = 0.46; p less than 0.01). There was a positive correlation between the sodium-lithium countertransport activity in red cells in the parents and their offspring when all parents and patients were considered (r = 0.37; p less than 0.001). CONCLUSIONS--Increased sodium-lithium countertransport activity in red cells in the parents of diabetic patients with nephropathy provides further evidence that familial, and possibly genetic, factors related to a predisposition to arterial hypertension have a role in the susceptibility of diabetic renal disease.
机译：目的确定糖尿病肾病患者红细胞钠锂逆转运活性是否存在家族性和遗传性。设计-病例对照研究。地点-教学医院糖尿病诊所。受试者--40胰岛素依赖型糖尿病患者，其父母都还活着：20名患有持续性蛋白尿和20名白蛋白排泄正常，这与年龄，糖尿病病程和体重指数相匹配。全部80位父母。主要观察指标-红细胞和动脉血压的钠锂逆转运活性。结果-蛋白尿患者的红细胞钠-锂逆转运活性高于正​​常白蛋白尿患者（平均（95％置信区间）0.47（0.39至0.54）v 0.33（0.28至0.38）mmol / l红细胞/ h分别为p = 0.0036；平均差异为0.14（0.04至0.22）。计算每个患者的两个父母的平均逆转运活性，并由此计算每组父母的平均值。蛋白尿患者的父母的血红蛋白值高于正常白蛋白尿患者的父母（0.40（0.32至0.48）v 0.30（0.26至0.33）mmol / l红细胞/ h，p = 0.016; 0.10（ 0.02至0.19））。蛋白尿患者的28位父母与正常白蛋白尿患者的12位父母相比，其逆转运活性高于所有80位父母的中位值（p小于0.001）。蛋白尿患者父母的平均动脉血压与其后代有关（r = 0.46； p小于0.01）。当考虑所有父母和患者时，父母及其后代中红细胞的钠-锂逆转运活性呈正相关（r = 0.37； p小于0.001）。结论-糖尿病肾病患者父母的红细胞中钠锂逆转运活性增加提供了进一步的证据，表明与动脉高血压易感性有关的家族性因素以及可能的遗传因素在糖尿病性肾病的易感性中起作用。

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