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首页> 美国卫生研究院文献>Canadian Journal of Comparative Medicine >Experimental swine vesicular disease pathology and immunofluorescence studies.
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Experimental swine vesicular disease pathology and immunofluorescence studies.

机译：实验性猪水泡病病理学和免疫荧光研究。

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Two day old piglets were inoculated intravenously with 1 ml of swine vesicular disease virus UK-G 27-72 isolate. Using infectivity tests, immunofluorescent staining and gross and histopathological examination, pathogenesis of the infection was studied in tissue specimens collected daily from one through seven days postinoculation. Swine vesicular disease virus had a strong affinity for the epithelia of the tongue, snout, coronary band and lips, the myocardium and the lymphoid elements of the tonsil and the brain stem. The virus had the greatest affinity for the epithelium of the tongue. However, there was no evidence that the tongue was the initial replication site for swine vesicular disease virus. Prickle cells in the stratum spinosum appear to be the primary targets for the virus. The necrotic foci in the stratum spinosum appeared first, followed the next day by reticular degeneration and multilocular intraepidermal vesicular formation. In the digestive tract and most of the other visceral organs the short duration and sudden drop of the virus titres and the negative fluorescence and pathological findings suggest that these are not important sites for the replication of swine vesicular disease virus in this experiment. The virus was recovered from most of the central nervous tissue specimens. Although the piglets had significant central nervous system lesions, signs of impaired central nervous system function were not detected. However, subtle nervous signs could have been obscured by difficulties in locomotion resulting from severe lesions of the feet.
机译：给两天大的仔猪静脉内接种1ml猪水泡病病毒UK-G 27-72分离株。使用感染性测试，免疫荧光染色以及肉眼和组织病理学检查，在接种后1至7天每天收集的组织样本中研究了感染的发病机理。猪水泡病病毒对舌头，鼻子，冠状动脉和嘴唇的上皮，扁桃体和脑干的心肌和淋巴样成分具有很强的亲和力。该病毒与舌头上皮的亲和力最大。但是，没有证据表明舌头是猪水泡病病毒的最初复制位点。刺状棘层中的刺细胞似乎是该病毒的主要靶标。棘突层中的坏死灶首先出现，然后第二天出现网状变性和多眼表皮内囊泡形成。在消化道和大多数其他内脏器官中，病毒滴度的持续时间短且突然下降，荧光和病理学结果阴性表明，这些不是该实验中猪水泡病病毒复制的重要部位。该病毒是从大多数中枢神经组织标本中回收的。尽管仔猪有明显的中枢神经系统病变，但未检测到中枢神经系统功能受损的迹象。然而，由于严重的脚部损伤而导致的运动困难可能掩盖了微妙的神经体征。

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