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Structural Basis of Ist1 Function and Ist1–Did2 Interaction in the Multivesicular Body Pathway and Cytokinesis

机译：Ist1功能和Ist1-Did2相互作用在多囊泡体通路和胞质分裂中的结构基础

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The ESCRT machinery functions in several important eukaryotic cellular processes. The AAA-ATPase Vps4 catalyzes disassembly of the ESCRT-III complex and may regulate membrane deformation and vesicle scission as well. Ist1 was proposed to be a regulator of Vps4, but its mechanism of action was unclear. The crystal structure of the N-terminal domain of Ist1 (Ist1NTD) reveals an ESCRT-III subunit-like fold, implicating Ist1 as a divergent ESCRT-III family member. Ist1NTD specifically binds to the ESCRT-III subunit Did2, and cocrystallization of Ist1NTD with a Did2 fragment shows that Ist1 interacts with the Did2 C-terminal MIM1 (MIT-interacting motif 1) via a novel MIM-binding structural motif. This arrangement indicates a mechanism for intermolecular ESCRT-III subunit association and may also suggest one form of ESCRT-III subunit autoinhibition via intramolecular interaction.

机译：ESCRT机制在几个重要的真核细胞过程中起作用。 AAA-ATPase Vps4催化ESCRT-III复合物的分解，并可能调节膜的变形和囊泡的分裂。有人提议Ist1是Vps4的调节子，但其作用机理尚不清楚。 Ist1（Ist1NTD）N末端域的晶体结构揭示了ESCRT-III亚基样的折叠，暗示Ist1为不同的ESCRT-III家族成员。 Ist1NTD与ESCRT-III亚基Did2特异性结合，Ist1NTD与Did2片段的共结晶显示Ist1通过新颖的MIM结合结构基序与Did2 C端MIM1（MIT相互作用基序1）相互作用。这种安排表明分子间ESCRT-III亚基缔合的机制，也可能建议通过分子内相互作用的一种形式的ESCRT-III亚基自抑制。

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期刊名称 Cell Regulation
作者
Junyu Xiao; Xiao-Wei Chen; Brian A. Davies; Alan R. Saltiel; David J. Katzmann; Zhaohui Xu;
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作者单位

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年(卷),期 2009(20),15
年度 2009
页码 3514–3524
总页数 11
原文格式 PDF
正文语种
中图分类细胞生物学;
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专利

1. Structural Basis of Ist1 Function and Ist1–Did2 Interaction in the Multivesicular Body Pathway and Cytokinesis [J] . Junyu Xiao, Xiao-Wei Chen, Brian A. Davies, Molecular biology of the cell . 2009,第15期

机译：Ist1功能和Ist1 – Did2相互作用在多囊泡体通路和细胞分裂中的结构基础
2. NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway [J] . Jie Shen, Zhongzheng Yang, Jiaolong Wang, Scientific reports. . 2016,第1期

机译：核磁共振研究酵母Vta1和Did2在多囊泡体分选途径中的相互作用。
3. Structural basis of Vta1 function in the multivesicular body sorting pathway [J] . Xiao JY, Xia HC, Zhou JH, Developmental cell . 2008,第1期

机译：Vta1功能在多泡体分选途径中的结构基础
4. The Presence of a Snf-like Protein Strenghtens a Role for EhADH in the Entamoeba histolytica Multivesicular Bodies Pathway [C] . C. Banuelos, I. Lopez-Reyes, G. Garcia-Rivera, European Congress on Tropical Medicine and International Health . 2007

机译：SNF样蛋白质的存在强化了在entamoeba组织olytica多猪体途径中的头部的作用
5. Structural basis of Vps4 function and regulation in the multivesicular body pathway. [D] . Xiao, Junyu. 2009

机译：Vps4功能的结构基础和多囊体途径中的调节。
6. NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway [O] . Jie Shen, Zhongzheng Yang, Jiaolong Wang, -1

机译：核磁共振研究酵母Vta1和Did2之间的相互作用在多囊泡体分选途径。
7. Structural Basis of Ist1 Function and Ist1–Did2 Interaction in the Multivesicular Body Pathway and Cytokinesis [O] . Xiao, Junyu, Chen, Xiao-Wei, Davies, Brian A., 2009

机译：Ist1功能和Ist1-Did2相互作用在多囊泡体通路和胞质分裂中的结构基础

Structural Basis of Ist1 Function and Ist1–Did2 Interaction in the Multivesicular Body Pathway and Cytokinesis

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