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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation

机译:单核细胞/巨噬细胞和CXCR3在复发性丙型肝炎和急性肝排斥反应肝移植后分化中的作用

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摘要

Objective Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection of the graft with HCV and acute cellular rejection (ACR) is essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation.
机译:在所有指南中,建议对晚期肝病和肝硬化患者进行客观的肝移植(LT)治疗,主要是HCV并发症。 HCV移植物再感染与急性细胞排斥(ACR)之间的区别非常重要,因为它们的处理方式不同。肝巨噬细胞可能是循环血液衍生的单核细胞(BDM)或常驻组织库普弗细胞引起的,在慢性肝损伤的发病机制中起着关键作用。这项工作的目的是评估巨噬细胞和免疫介质CXCR3的来源是否可以帮助区分肝移植后急性复发的HCV和ACR。

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