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首页> 美国卫生研究院文献>Clinical and Developmental Immunology >Differential Transcript Profiles of MHC Class Ib(Qa-1 Qa-2 and Qa-10) and Aire Genes during the Ontogeny of Thymus and Other Tissues
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Differential Transcript Profiles of MHC Class Ib(Qa-1 Qa-2 and Qa-10) and Aire Genes during the Ontogeny of Thymus and Other Tissues

机译：胸腺和其他组织发育过程中MHC Ib类（Qa-1Qa-2和Qa-10）和Aire基因的差异转录谱

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Qa-2 and Qa-1 are murine nonclassical MHC class I molecules involved in the modulation of immune responses by interacting with T CD8+ and NK cell inhibitory receptors. During thymic education, the Aire gene imposes the expression of thousands of tissue-related antigens in the thymic medulla, permitting the negative selection events. Aiming to characterize the transcriptional profiles of nonclassical MHC class I genes in spatial-temporal association with the Aire expression, we evaluated the gene expression of H2-Q7(Qa-2), H2-T23(Qa-1), H2-Q10(Qa-10), and Aire during fetal and postnatal development of thymus and other tissues. In the thymus, H2-Q7(Qa-2) transcripts were detected at high levels throughout development and were positively correlated with Aire expression during fetal ages. H2-Q7(Qa-2) and H2-T23(Qa-1) showed distinct expression patterns with gradual increasing levels according to age in most tissues analyzed. H2-Q10(Qa-10) was preferentially expressed by the liver. The Aire transcriptional profile showed increased levels during the fetal period and was detectable in postnatal ages in the thymus. Overall, nonclassical MHC class I genes started to be expressed early during the ontogeny. Their levels varied according to age, tissue, and mouse strain analyzed. This differential expression may contribute to the distinct patterns of mouse susceptibility/resistance to infectious and noninfectious disorders.
机译：Qa-2和Qa-1是鼠类非经典MHC I类分子，通过与T CD8 + 和NK细胞抑制受体相互作用来参与免疫应答的调节。在胸腺教育过程中，Aire基因使胸腺髓质中成千上万种与组织相关的抗原表达，从而导致阴性选择事件。为了表征非经典MHC I类基因与Aire表达的时空关联的转录特征，我们评估了H2-Q7（Qa-2），H2-T23（Qa-1），H2-Q10（ Qa-10）和Aire在胎儿和产后胸腺和其他组织的发育过程中。在胸腺中，在整个发育过程中均检测到高水平的H2-Q7（Qa-2）转录物，并且与胎儿年龄中的Aire表达呈正相关。在大多数被分析的组织中，H2-Q7（Qa-2）和H2-T23（Qa-1）表现出不同的表达模式，并随着年龄的增长而逐渐增加。 H2-Q10（Qa-10）优先由肝脏表达。 Aire转录谱显示在胎儿期水平升高，在出生后的胸腺中可检测到。总体而言，非经典的MHC I类基因在个体发育早期就开始表达。它们的水平根据年龄，组织和所分析的小鼠品系而变化。这种差异表达可能有助于小鼠对传染性和非传染性疾病的易感性/抗性的不同模式。

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