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首页> 美国卫生研究院文献>Clinical and Diagnostic Laboratory Immunology >Cocaine Causes Increased Type I Interferon Secretion by both L929 Cells and Murine Macrophages
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Cocaine Causes Increased Type I Interferon Secretion by both L929 Cells and Murine Macrophages

机译：可卡因引起L929细胞和小鼠巨噬细胞的I型干扰素分泌增加

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摘要

Cocaine has been demonstrated to have a number of different effects on immune cell functions. We have reported alterations of cellular functions by macrophages (Mφ) exposed to cocaine in vitro, including the inhibition of mouse hepatitis virus replication. Here, we present evidence that cocaine stimulates the secretion of an antiviral product that is neutralized by anti-interferon (anti-IFN). A dose-dependent increase in the secretion of IFN by both Mφ and L929 cells incubated with cocaine, with a concomitant decrease in virus replication, is also reported. The increase in IFN secretion was most pronounced when cells were cultured in the presence of the IFN inducer poly(I·C). The effect of cocaine on IFN production was found to be primarily at the transcript level in both Mφ and L929 cells. These findings further support our previous research demonstrating an antiviral activity of cocaine in vitro. The relevance of this activity to viral infections in general remains to be determined.
机译：可卡因已被证明对免疫细胞功能有许多不同的作用。我们已经报道了在体外暴露于可卡因的巨噬细胞（Mφ）对细胞功能的改变，包括抑制小鼠肝炎病毒复制。在这里，我们提供了可卡因刺激抗干扰素（anti-IFN）中和的抗病毒产品分泌的证据。还报道了与可卡因一起孵育的Mφ和L929细胞的IFN分泌呈剂量依赖性增加，同时伴随病毒复制的减少。当细胞在IFN诱导剂poly（I·C）存在下培养时，IFN分泌的增加最为明显。发现可卡因对IFN产生的影响主要在Mφ和L929细胞两者的转录水平上。这些发现进一步支持了我们先前的研究，证实了可卡因在体外具有抗病毒活性。总体而言，该活性与病毒感染的相关性尚待确定。

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