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首页> 美国卫生研究院文献>Clinical and Diagnostic Laboratory Immunology >Kinetics of Decline of Maternal Measles Virus-Neutralizing Antibodies in Sera of Infants in France in 2006
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Kinetics of Decline of Maternal Measles Virus-Neutralizing Antibodies in Sera of Infants in France in 2006

机译：2006年法国婴幼儿血清中麻疹病毒中和抗体的下降动力学

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The optimal age for measles vaccination is an important health issue, since maternal antibodies may neutralize the vaccine antigen before a specific immune response develops, while delaying vaccination may increase the risk of complicated diseases in infants. However, measles vaccination impacts the duration of protection afforded by transplacental transfer of maternal antibodies: vaccination-induced maternal antibodies disappear faster than disease-induced antibodies. In order to maintain protection against measles in infants, it is important to monitor the dynamics of this phenomenon in vaccinated populations. To assess the current situation in France, a multicenter, prospective seroepidemiological study was conducted in seven French hospitals between October 2005 and January 2007. Maternal measles antibody concentrations from 348 infants 0 to 15 months old were measured using the plaque reduction neutralization assay. Geometric mean concentrations and the percentage of infants with maternal measles antibody concentrations above the protection threshold (≥120 mIU/ml) were assessed according to age. Results show that after more than 20 years of routine measles vaccination in France, maternal measles-neutralizing antibodies decrease dramatically in French infants by 6 months of age, from 1,740 mIU/ml for infants 0 to 1 month old to 223 mIU/ml for infants 5 to 6 months old, and that 90% of infants are not protected against measles after 6 months of age. Infant protection against measles could be optimized both by increasing herd immunity through an increased vaccine coverage and by lowering the age of routine vaccination from 12 to 9 months.
机译：麻疹疫苗接种的最佳年龄是一个重要的健康问题，因为母体抗体可能在特定的免疫应答发生之前中和疫苗抗原，而延迟疫苗接种可能会增加婴儿患复杂疾病的风险。但是，麻疹疫苗接种会影响通过胎盘转移母源抗体提供的保护时间：疫苗诱导的母源抗体的消失速度快于疾病诱导的抗体。为了维持对婴儿预防麻疹的保护，重要的是要监测接种疫苗人群中这种现象的动态。为了评估法国的当前状况，2005年10月至2007年1月间，在法国的7家医院进行了多中心，前瞻性血清流行病学研究。使用噬斑减少中和测定法测量了348名0至15个月大婴儿的母亲麻疹抗体浓度。根据年龄评估几何平均浓度和母体麻疹抗体浓度高于保护阈值（≥120mIU / ml）的婴儿的百分比。结果表明，在法国进行了20多年的常规麻疹疫苗接种后，法国婴儿到6个月大时的中和性麻疹中和抗体急剧下降，从0到1个月大的婴儿为1,740 mIU / ml，婴儿为223 mIU / ml 5至6个月大，并且90％的婴儿在6个月大后没有受到麻疹的保护。可以通过增加疫苗覆盖率提高牛群免疫力，以及将常规疫苗接种的年龄从12个月降低至9个月，来优化婴儿的麻疹防护。

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