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Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output

机译：详细的代谢途径检查对2例嗜铬细胞瘤儿茶酚胺总输出量增加最小的诊断价值

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Two patients with phaeochromocytoma having atypical biochemical features are described. Total catecholamine excretion was normal in one and only slightly raised in the other; both had a diagnostic rise in output of metadrenaline and 4-hydroxy-3-methoxymandelic acid whilst 4-hydroxy-3-methoxyphenylglycol excretion was increased in one of them. During hypertensive attacks adrenaline excretion became greater than that of noradrenaline. The diagnostic usefulness of separate adrenaline and noradrenaline estimations in addition to catecholamine metabolite assay is discussed. A lack of relationship between tumour catecholamine content and urinary catecholamine output is emphasized.

机译：描述了两名具有非典型生化特征的嗜铬细胞瘤患者。儿茶酚胺的总排泄在一个是正常的，而在另一个则仅轻微升高；两者均诊断出美肾上腺素和4-羟基-3-甲氧基扁桃酸的输出增加，而其中之一的4-羟基-3-甲氧基苯基乙二醇排泄增加。在高血压发作期间，肾上腺素的排泄量大于去甲肾上腺素。讨论了除了儿茶酚胺代谢物测定法以外的单独的肾上腺素和去甲肾上腺素评估方法的诊断价值。强调了肿瘤儿茶酚胺含量和尿儿茶酚胺输出之间的关系。

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期刊名称 Clinical Molecular Pathology
作者
J. J. Brown; C. R. J. Ruthven; M. Sandler;
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作者单位

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年(卷),期 1966(19),5
年度 1966
页码 482–486
总页数 5
原文格式 PDF
正文语种
中图分类病理学;
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1. Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma. [J] . Hickman PE, Leong M, Chang J, Pathology . 2009,第2期

机译：在研究嗜铬细胞瘤方面，无血浆的肾上腺素优于尿液和血浆儿茶酚胺和尿液儿茶酚胺代谢物。
2. Consideration of the degree of increase in urine metadrenalines provides superior specificity in the diagnosis of phaeochromocytoma than additional urine catecholamine measurement. [J] . J J Scargill, P Reed, J Kane Annals of clinical biochemistry. . 2013,第1期

机译：尿中肾上腺素的增加程度的考虑提供了在嗜铬细胞瘤的诊断中比其他尿中儿茶酚胺测量更好的特异性。
3. Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients. [J] . Burton TJ, Azizan EA, Brown MJ European Journal of Pharmacology: An International Journal . 2011,第1a3期

机译：研究醛固酮反应途径在从Conn和嗜铬细胞瘤患者获得的原代人肾上腺皮质细胞中的功能。
4. Identifying Necessary Reactions in Metabolic Pathways by Minimal Model Generation [C] . Takehide Soh, Katsumi Inoue European Conference on Artificial Intelligence . 2010

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机译：一项使用代谢组学的前瞻性先导研究揭示了特定的脂肪酸儿茶酚胺和色氨酸代谢途径可能是严重创伤后阴性结果的可能预测因子
7. Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output [O] . Brown, J. J., Ruthven, C. R. J., Sandler, M. 1966

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Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output

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