首页> 美国卫生研究院文献>Clinical Molecular Pathology >Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors.
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Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors.

机译:雄激素受体在乳房的顶泌化生和顶泌腺腺瘤中的免疫组织化学定位:与雌激素和孕激素受体的关系。

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摘要

AIM: To investigate the receptor status of the sex steroid hormones in apocrine metaplasia of the breast. METHODS: 82 cases of apocrine metaplasia, including 18 of the rare lesion apocrine adenosis, were studied immunohistochemically for the expression of androgen receptor, oestrogen receptor, and progesterone receptor proteins on formalin fixed, paraffin embedded tissue sections. The standard avidin biotin complex (ABC) technique was followed and appropriate positive and negative controls were used. RESULTS: All the studied cases (82/82) were positive for androgen receptor, but were negative for oestrogen receptor and progesterone receptor. CONCLUSIONS: Apocrine metaplastic epithelium, unlike the normal breast epithelium, is responsive to androgens, through androgen receptors, rather than to the female sex hormones. This may have clinical implications.
机译:目的:探讨乳腺顶泌化生中性类固醇激素的受体状态。方法:免疫组织化学方法研究了82例顶泌化生,包括18种罕见病灶顶分泌腺瘤,在福尔马林固定,石蜡包埋的组织切片上检测了雄激素受体,雌激素受体和孕激素受体蛋白的表达。遵循标准的抗生物素蛋白生物素复合物(ABC)技术,并使用适当的阳性和阴性对照。结果:所有研究病例(82/82)的雄激素受体均为阳性,而雌激素受体和孕激素受体均为阴性。结论:与正常的乳腺上皮不同,顶泌的化生上皮对雄激素的反应是通过雄激素受体而不是雌性激素。这可能具有临床意义。

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