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Structure Expression and Function of ICAM-5

机译：ICAM-5的结构表达和功能

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摘要

Cell adhesion is of utmost importance in normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin, TLN) is a member of the ICAM family of adhesion proteins. As a novel cell adhesion molecule, ICAM-5 shares many structural similarities with the other members of IgSF, especially the ICAM subgroup; however, ICAM-5 has several unique properties compared to the other ICAMs. With its nine extracellular Ig domains, ICAM-5 is the largest member of ICAM subgroup identified so far. Therefore, it is much more complex than the other ICAMs. The expression of ICAM-5 is confined to the telencephalic neurons of the central nervous system whereas all the other ICAM members are expressed mostly by cells in the immune and blood systems. The developmental appearance of ICAM-5 parallels the time of dendritic elongation and branching, and synapse formation in the telencephalon. As a somatodendrite-specific adhesion molecule, ICAM-5 not only participates in immune-nervous system interactions, it could also participate in neuronal activity, Dendrites' targeting signals, and cognition. It would not be surprising if future investigations reveal more binding partners and other related functions of ICAM-5.
机译：在正常发育和细胞功能中，细胞粘附至关重要。 ICAM-5（细胞间粘附分子5，端脑，TLN）是ICAM粘附蛋白家族的成员。作为一种新型的细胞粘附分子，ICAM-5与IgSF的其他成员（尤其是ICAM亚组）具有许多结构相似性。但是，与其他ICAM相比，ICAM-5具有几个独特的属性。凭借其9个胞外Ig结构域，ICAM-5是迄今为止确定的ICAM亚组的最大成员。因此，它比其他ICAM复杂得多。 ICAM-5的表达仅限于中枢神经系统的端脑神经元，而所有其他ICAM成员则主要由免疫和血液系统中的细胞表达。 ICAM-5的发育外观与树突伸长和分支时间以及端脑中突触形成的时间平行。 ICAM-5作为一种体生树突状细胞特异性粘附分子，不仅参与免疫神经系统的相互作用，还可以参与神经元活动，树突状细胞的靶向信号和认知。如果将来的调查显示出更多具有约束力的伙伴和ICAM-5的其他相关功能，也就不足为奇了。

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