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首页> 美国卫生研究院文献>Comparative and Functional Genomics >Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer
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Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer

机译：damselae亚种光细菌的完整基因组序列。从深海网箱养殖的鲈鱼中分离出带有脓毒性皮肤溃疡的damselae菌株SSPD1601

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Photobacterium damselae subsp. damselae (PDD) is a Gram-negative bacterium that can infect a variety of aquatic organisms and humans. Based on an epidemiological investigation conducted over the past 3 years, PDD is one of the most important pathogens causing septic skin ulcer in deep-sea cage-cultured Sebastes schlegelii in the Huang-Bohai Sea area and present throughout the year with high abundance. To further understand the pathogenicity of this species, the pathogenic properties and genome of PDD strain SSPD1601 were analyzed. The results revealed that PDD strain SSPD1601 is a rod-shaped cell with a single polar flagellum, and the clinical symptoms were replicated during artificial infection. The SSPD1601 genome consists of two chromosomes and two plasmids, totaling 4,252,294 bp with 3,751 coding sequences (CDSs), 196 tRNA genes, and 47 rRNA genes. Common virulence factors including flagellin, Fur, RstB, hcpA, OMPs, htpB-Hsp60, VasK, and vgrG were found in strain SSPD1601. Furthermore, SSPD1601 is a pPHDD1-negative strain containing the hemolysin gene hlyAch and three putative hemolysins (emrA, yoaF, and VPA0226), which are likely responsible for the pathogenicity of SSPD1601. The phylogenetic analysis revealed SSPD1601 to be most closely related to Phdp Wu-1. In addition, the antibiotic resistance phenotype indicated that SSPD1601 was not sensitive to ceftazidime, pipemidic, streptomycin, cefalexin, bacitracin, cefoperazone sodium, acetylspiramycin, clarithromycin, amikacin, gentamycin, kanamycin, oxacillin, ampicillin, and trimethoprim-sulfamethoxazole, but only the bacitracin resistance gene bacA was detected based on Antibiotic Resistance Genes Database. These results expand our understanding of PDD, setting the stage for further studies of its pathogenesis and disease prevention.
机译：damselae细菌亚种。 damselae（PDD）是一种革兰氏阴性细菌，可感染多种水生生物和人类。根据过去三年的流行病学调查，PDD是黄渤海地区深海网箱养殖的塞巴斯蒂氏schlegelii引起败血症性皮肤溃疡的最重要病原体之一，并且全年呈高水平存在。为了进一步了解该物种的致病性，分析了PDD菌株SSPD1601的致病特性和基因组。结果表明，PDD菌株SSPD1601是具有单个极鞭毛的杆状细胞，在人工感染期间复制了临床症状。 SSPD1601基因组由两条染色体和两个质粒组成，共4,252,294 bp，具有3,751个编码序列（CDS），196个tRNA基因和47个rRNA基因。在菌株SSPD1601中发现了常见的毒力因子，包括鞭毛蛋白，Fur，RstB，hcpA，OMP，htpB-Hsp60，VasK和vgrG。此外，SSPD1601是pPHDD1阴性菌株，含有溶血素基因hlyAch和三种推定的溶血素（emrA，yoaF和VPA0226），这可能是SSPD1601致病性的原因。系统发育分析表明SSPD1601与Phdp Wu-1最为相关。另外，抗生素抗性表型表明SSPD1601对头孢他啶，哌啶类，链霉素，头孢氨苄，杆菌肽，头孢哌酮钠，乙酰螺旋霉素，克拉霉素，阿米卡星，庆大霉素，卡那霉素，奥沙西林，苄青霉素，氨苄青霉素和丁甲嘧啶不敏感基于抗生素抗性基因数据库检测抗性基因bacA。这些结果扩大了我们对PDD的理解，为进一步研究PDD的发病机理和疾病预防奠定了基础。

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