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The AvecNet Trial to assess whether addition of pyriproxyfen an insect juvenile hormone mimic to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial

机译：AvecNet试验旨在评估在布基纳法索农村地区对拟除虫菊酯有抗药性的地区中除目前的最佳实践外在持久的杀虫蚊帐中添加吡虫洛芬（一种昆虫幼体激素模拟物）是否可提供针对临床疟疾的额外保护：随机对照试验

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BackgroundRecent reductions in malaria in sub-Saharan Africa have been associated with increased coverage with long-lasting insecticidal nets (LLINs). Pyrethroids are currently the only insecticide class used for treating nets, and the rapid increase in resistance to pyrethroids in vector mosquitoes may jeopardise future vector control. Nets containing a novel combination of permethrin, a pyrethroid, and pyriproxyfen, an insect juvenile hormone mimic, (PPF-LLIN) may enhance malaria control, as well as reducing the spread of pyrethroid-resistant mosquitoes. This trial will determine whether PPF-LLINs provide incremental protection against malaria over current best practice of LLINs and prompt treatment in an area with pyrethroid-resistant vectors.

机译：背景撒哈拉以南非洲地区最近疟疾的减少与持久杀虫网（LLIN）的覆盖率增加有关。拟除虫菊酯是目前唯一用于处理蚊帐的杀虫剂，媒介蚊子对拟除虫菊酯的抗性迅速增加可能会危害未来的媒介控制。含有苄氯菊酯，拟除虫菊酯和吡虫杀酚（一种昆虫幼年激素模拟物）（PPF-LLIN）的新型组合的蚊帐可增强疟疾控制能力，并减少对拟除虫菊酯的抗性蚊子的传播。该试验将确定PPF-LLIN是否比当前的LLIN最佳实践提供了针对疟疾的增量保护，并在具有拟除虫菊酯抗药性的地区迅速治疗。

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期刊名称 Current Controlled Trials in Cardiovascular Medicine
作者
Alfred B Tiono; Margaret Pinder; Sagnon N’Fale; Brian Faragher; Tom Smith; Mariabeth Silkey; Hilary Ranson; Steve W Lindsay;
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作者单位

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年(卷),期 2015(16),-1
年度 2015
页码 113
总页数 12
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Insecticide resistance management Malaria control Insecticide-treated bed net Pyrethroid Pyriproxyfen Insect juvenile hormone mimic Clinical malaria Entomological inoculation rate Cluster randomized controlled trial;

机译：杀虫剂抗性管理;疟疾控制;经杀虫剂处理的蚊帐;拟除虫菊酯;吡P氧基;昆虫幼体激素模拟物;临床疟疾;昆虫学接种率;整群随机对照试验;

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外文文献

1. The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial [J] . Alfred B Tiono, Margaret Pinder, Sagnon N’Fale, Trials . 2015,第1期

机译：AvecNet试验评估了在长效杀虫蚊帐中是否添加除虫幼激素模拟物吡ip昔芬是否比目前最佳做法在布基纳法索农村地区具有拟除虫菊酯抗性载体的地区提供了针对临床疟疾的额外保护：随机对照试验
2. To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised trial [J] . Margaret Pinder, Musa Jawara, Lamin BS Jarju, Trials . 2011,第1期

机译：评估室内残留喷洒剂是否可以提供比目前冈比亚长效杀虫蚊帐最佳实践更好的针对临床疟疾的保护：一项两臂类群随机试验的研究方案
3. Efficacy of Olyset Duo, a bednet containing pyriproxyfen and permethrin, versus a permethrin-only net against clinical malaria in an area with highly pyrethroid-resistant vectors in rural Burkina Faso: a cluster-randomised controlled trial [J] . Tiono Alfred B., Ouedraogo Alphonse, Ouattara Daouda, The Lancet . 2018,第10147期

机译：olyset Duo，一种含有吡匹昔芬和Permethrin的蚊帐，与仅在农村农村的抗咬合抗性矢量的临床疟疾中对临床疟疾进行临床疟疾的疗效：群集随机对照试验
4. To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised trial [O] . Margaret Pinder, Musa Jawara, Lamin BS Jarju, 2011

机译：评估室内残留喷雾剂是否可以提供比目前冈比亚长效杀虫蚊帐最佳实践更好的针对临床疟疾的保护：一项两臂类群随机试验的研究方案
5. The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial [O] . Alfred B Tiono, Margaret Pinder, Sagnon N’Fale, 2015

机译：AvecNet试验旨在评估在布基纳法索农村地区对拟除虫菊酯有抗药性的地区中，除目前的最佳实践外，在持久的杀虫蚊帐中添加吡虫洛芬（一种昆虫幼体激素模拟物）是否可提供针对临床疟疾的额外保护：随机对照试验

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