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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >The Relationship between Environmental Tobacco Smoke Exposure and Cardiovascular Disease and the Potential Modifying Effect of Diet in a Prospective Cohort among American Indians: The Strong Heart Study
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The Relationship between Environmental Tobacco Smoke Exposure and Cardiovascular Disease and the Potential Modifying Effect of Diet in a Prospective Cohort among American Indians: The Strong Heart Study

机译：美洲印第安人预期队列中环境烟草烟雾暴露与心血管疾病之间的关系以及饮食的潜在调节作用：强心研究

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摘要

American Indians experience high rates of cardiovascular diseases (CVD). Environmental tobacco smoke (ETS) has been linked to CVD, possibly due to pro-inflammatory and oxidative stress pathways. We examined the relationship between self-reported exposure to ETS and fatal and nonfatal CVD incidence using Cox proportional hazards models among 1843 non-smoking American Indians participating in the Strong Heart Study. We also evaluated potential modifying effects of several dietary nutrients high in anti-inflammatory and anti-oxidant properties with ETS exposure on fatal and nonfatal CVD by creating interaction terms between ETS exposure and the dietary variable. Participants exposed to ETS had a higher hazard (hazard ratio: 1.22; 95% confidence interval, 1.03 to 1.44) for developing CVD compared to persons not exposed. Interaction analyses suggested stronger effects of ETS on CVD incidence among those consuming diets lower in vitamin E as compared to those consuming higher amounts, particularly on the additive scale. Additional research is recommended to clarify whether public health prevention strategies should simultaneously target reductions in ETS exposures and improvements in diets that may exceed the expected benefits of targeting these risk factors separately.
机译：美洲印第安人患心血管疾病（CVD）的比例很高。可能由于促炎和氧化应激途径，环境烟草烟雾（ETS）与CVD相关。我们使用Cox比例风险模型在参加“强心研究”的1843个非吸烟的美洲印第安人中检查了自我报告的ETS暴露与致命和非致命CVD发生率之间的关系。我们还通过建立ETS暴露量与饮食变量之间的相互作用项，评估了几种具有高抗炎和抗氧化特性的饮食营养素对ETS暴露对致命和非致命CVD的潜在调节作用。与未接触ETS的人相比，接触ETS的参与者发生CVD的危险性更高（危险比：1.22； 95％置信区间为1.03至1.44）。交互作用分析表明，与摄入较高维生素E的饮食相比，摄入维生素E较低的饮食中的ETS对CVD发生率的影响更大，尤其是在添加剂量方面。建议进行更多研究，以阐明公共卫生预防策略是否应同时针对减少ETS暴露和改善饮食以超过单独针对这些危险因素的预期收益为目标。

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