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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Residential Proximity to Major Roadways and Risk of Type 2 Diabetes Mellitus: A Meta-Analysis
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Residential Proximity to Major Roadways and Risk of Type 2 Diabetes Mellitus: A Meta-Analysis

机译：住宅附近主要道路和2型糖尿病的风险：荟萃分析

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Research indicates that higher levels of traffic-related pollution exposure increase the risk of diabetes, but the association between road proximity and diabetes risk remains unclear. To assess and quantify the association between residential proximity to major roadways and type 2 diabetes, a systematic review and meta-analysis was performed. Embase, Medline, and Web of Science were searched for eligible studies. Using a random-effects meta-analysis, the summary relative risks (RRs) were calculated. Bayesian meta-analysis was also performed. Eight studies (6 cohort and 2 cross-sectional) with 158,576 participants were finally included. The summary unadjusted RR for type 2 diabetes associated with residential proximity to major roadways was 1.24 (95% confidence interval [CI]: 1.07–1.44, p = 0.001, I2 = 48.1%). The summary adjusted RR of type 2 diabetes associated with residential proximity to major roadways was 1.12 (95% CI: 1.03–1.22, p = 0.01, I2 = 17.9%). After excluding two cross-sectional studies, the summary results suggested that residential proximity to major roadways could increase type 2 diabetes risk (Adjusted RR = 1.13; 95% CI: 1.02–1.27, p = 0.025, I2 = 36.6%). Bayesian meta-analysis showed that the unadjusted RR and adjusted RR of type 2 diabetes associated with residential proximity to major roadways were 1.22 (95% credibility interval: 1.06–1.55) and 1.13 (95% credibility interval: 1.01–1.31), respectively. The meta-analysis suggested that residential proximity to major roadways could significantly increase risk of type 2 diabetes, and it is an independent risk factor of type 2 diabetes. More well-designed studies are needed to further strengthen the evidence.
机译：研究表明，较高水平的交通相关污染暴露会增加糖尿病的风险，但道路接近度与糖尿病风险之间的关联仍不清楚。为了评估和量化居住在主要道路附近与2型糖尿病之间的关联，进行了系统的回顾和荟萃分析。搜索了Embase，Medline和Web of Science，以寻找符合条件的研究。使用随机效应荟萃分析，计算了相对危险度（RRs）。还进行了贝叶斯荟萃分析。最终纳入八项研究（6项队列研究和2项横断面研究），共有158,576名参与者。与居住在主要道路附近的居民相关的2型糖尿病的未经调整的总RR为1.24（95％置信区间[CI]：1.07-1.44，p = 0.001，I 2 = 48.1％）。与居住在主要道路附近的居民相关的2型糖尿病的汇总调整后RR为1.12（95％CI：1.03-1.22，p = 0.01，I 2 = 17.9％）。在排除两项横断面研究之后，汇总结果表明，居住在主要道路附近可能会增加2型糖尿病的风险（调整后RR = 1.13； 95％CI：1.02-1.27，p = 0.025，I 2 = 36.6％）。贝叶斯荟萃分析显示，与居住在主要道路附近的居民相关的2型糖尿病的未经调整的RR和经调整的RR分别为1.22（95％可信区间：1.06-1.55）和1.13（95％可信区间：1.01-1.31）。荟萃分析表明，靠近主要道路的居民区可能会显着增加2型糖尿病的风险，并且它是2型糖尿病的独立危险因素。需要进行更精心设计的研究以进一步加强证据。

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