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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Evaluation by the Ames Assay of the Mutagenicity of UV Filters Using Benzophenone and Benzophenone-1
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Evaluation by the Ames Assay of the Mutagenicity of UV Filters Using Benzophenone and Benzophenone-1

机译：苯甲酮和苯甲酮-1的紫外线滤光片致突变性的艾姆斯分析的评价

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摘要

Ultraviolet absorbing chemicals (UV filters) are widely used in personal care products for protecting human skin and hair from damage by UV radiation. Although these substances are released into the environment during production and consumption processes, little is known about their genotoxicity effects. Our previous studies have shown that benzophenone-type UV filters exhibited acute toxicity on three species of aquatic organisms. Mutagenesis by benzophenone (BP) and benzophenone-1(BP-1) was tested in the present study by the Salmonella typhimurium/reverse mutation assay (Ames assay). All the positive reverse mutations occurred in the absence of the S9 liver extract system for both chemicals. From BP, positive mutation effects on the TA102 strain at doses of 0.05 μg/plate and 0.5 μg/plate were detected. From BP-1, positive mutation effects on the TA97 strain at doses of 0.05 μg/plate and 0.5 μg/plate, and on the TA100 strain at a dose of 0.5 μg/plate, were detected. A mixture of BP and BP-1 exhibited mutagenicity on the TA97 and TA100 strains. For the TA97 strain, the positive mutation results were detected at 10% and 50% of the mixture. For the TA100 strain, the results were detected when the mixture was at 5% and 10%. In the mixture at 5%, the concentrations of BP and BP-1 were 3.5 μg/plate and 14 μg/plate, respectively. In the 10% mixture, the doses of BP and BP-1 were 7 μg/plate and 28 μg/plate, respectively. In the 50% mixture, the doses of BP and BP-1 were 35 μg/plate and 140 μg/plate, respectively. The mixture test results suggested that there was antagonism in mutagenicity between BP and BP-1.
机译：紫外线吸收化学品（紫外线过滤剂）广泛用于个人护理产品中，以保护人体皮肤和头发免受紫外线辐射的损害。尽管这些物质在生产和消费过程中释放到环境中，但对其遗传毒性的影响知之甚少。我们以前的研究表明，二苯甲酮型紫外线过滤剂对三种水生生物均表现出急性毒性。在本研究中，通过鼠伤寒沙门氏菌/反向突变试验（Ames试验）测试了二苯甲酮（BP）和二苯甲酮-1（BP-1）的诱变作用。所有两种化学药品均在没有S9肝提取物系统的情况下发生所有正向反向突变。从BP中，检测到0.05μg/板和0.5μg/板的剂量对TA102菌株的正突变作用。从BP-1，检测到0.05μg/板和0.5μg/板的剂量对TA97菌株和0.5μg/板的剂量对TA100菌株的正突变作用。 BP和BP-1的混合物对TA97和TA100菌株表现出致突变性。对于TA97菌株，在混合物的10％和50％处检测到阳性突变结果。对于TA100菌株，当混合物分别为5％和10％时检测到结果。在5％的混合物中，BP和BP-1的浓度分别为3.5μg/板和14μg/板。在10％的混合物中，BP和BP-1的剂量分别为7μg/板和28μg/板。在50％的混合物中，BP和BP-1的剂量分别为35μg/板和140μg/板。混合测试结果表明，BP和BP-1之间的致突变性存在拮抗作用。

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