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首页> 美国卫生研究院文献>International Journal of Breast Cancer >Intraoperative Full-Dose of Partial Breast Irradiation with Electrons Delivered by Standard Linear Accelerators for Early Breast Cancer
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Intraoperative Full-Dose of Partial Breast Irradiation with Electrons Delivered by Standard Linear Accelerators for Early Breast Cancer

机译：术中用标准线性加速器传递的电子对乳房局部照射进行全剂量早期乳腺癌治疗。

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Purpose. To assess feasibility, efficacy, toxicity, and cosmetic results of intraoperative radiotherapy (IORT) with electrons delivered by standard linear accelerators (Linacs) during breast conserving surgeries for early infiltrating breast cancer (BC) treatment. Materials and Methods. A total of 152 patients with invasive ductal carcinoma (T ≤ 3.0 cm) at low risk for local relapses were treated. All had unicentric lesions by imaging methods and negative sentinel node. After a wide local excision, 21 Gy were delivered on the parenchyma target volume with electron beams. Local recurrences (LR), survival, toxicity, and cosmetic outcomes were analyzed. Results. The median age was 58.3 years (range 40–85); median follow-up was 50.7 months (range 12–101.5). There were 5 cases with LR, 2 cases with distant metastases, and 2 cases with deaths related to BC. The cumulative incidence rates of LR, distant metastases, and BC death were 3.2%, 1.5%, and 1.5%, respectively. Complications were rare, and the cosmetic results were excellent or good in most of the patients. Conclusions. IORT with electrons delivered by standard Linacs is feasible, efficient, and well tolerated and seems to be beneficial for selected patients with early infiltrating BC.
机译：目的。评估术中放疗（IORT）的可行性，功效，毒性和美容效果，这些术式是在早期浸润性乳腺癌（BC）治疗的保乳手术中，通过标准线性加速器（Linacs）输送的电子进行的。材料和方法。共治疗152例局部复发风险低的浸润性导管癌（T≤3.0cm）患者。影像学检查均显示单中心病变，前哨淋巴结阴性。广泛的局部切除后，用电子束将21 Gy传递到实质目标体积上。分析了局部复发（LR），生存率，毒性和美容效果。结果。中位年龄为58.3岁（范围40-85）；中位随访时间为50.7个月（范围12–101.5）。 LR患者5例，远处转移2例，与BC相关的死亡2例。 LR，远处转移和BC死亡的累积发生率分别为3.2％，1.5％和1.5％。并发症很少见，大多数患者的美容效果均良好或良好。结论。通过标准直线加速器传递电子的IORT是可行，高效且耐受性良好的，似乎对某些早期浸润BC的患者有益。

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