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首页> 美国卫生研究院文献>The International Journal of Angiology : Official Publication of the International College of Angiology Inc >Ranolazine Therapy Reduces Non-ST-Segment-Elevation Myocardial Infarction and Unstable Angina in Coronary Disease Patients with Angina
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Ranolazine Therapy Reduces Non-ST-Segment-Elevation Myocardial Infarction and Unstable Angina in Coronary Disease Patients with Angina

机译：雷诺嗪治疗可减轻冠心病心绞痛患者的非ST段抬高心肌梗死和不稳定型心绞痛

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High sympathetic tone and cardiac autonomic neuropathy (CAN) are associated with major adverse cardiac events (MACE). We have shown ranolazine (RAN) improves autonomic function. RAN was introduced to 51 successive anginal CD patients (RANCD). A control group of 54 successive nonanginal CD patients (NORANCD) continued baseline therapy. Mean study duration was 6.1 years, which included semi-annual autonomic function measures (ANX 3.0, ANSAR Medical Technologies, Inc., Philadelphia, PA) and yearly myocardial perfusion SPECT studies (MPI). MACE were experienced by 29% RANCD patients versus 46% NORANCD patients (p = 0.0105). The patients from both groups with abnormal parasympathetic and sympathetic (P&S) measures and MACE totaled 52 of those patients with MACE versus 17% of those patients without MACE (p = 0.0274). Abnormal MPI was demonstrated in 35% of those with abnormal (P&S) measures and MACE versus 12% without MACE. Sympathovagal balance (SB) was lower, indicating higher, relative parasympathetic tone (known to be cardioprotective) in the RANCD group. Acute coronary syndromes occurred 4.5 times as often in NORANCD patients. High SB occur more frequently than abnormal MPI in CD patients experiencing MACE. In addition to increased myocardial blood flow as its proposed mechanism of angina relief, RAN improves P&S measures, a potentially new mechanism whereby RAN improves outcomes.
机译：高交感神经张力和心脏自主神经病（CAN）与主要不良心脏事件（MACE）相关。我们显示了雷诺嗪（RAN）可以改善植物神经功能。 RAN被介绍给51位连续的心绞痛CD患者（RANCD）。对照组54位连续的非心绞痛CD患者（NORANCD）继续进行基线治疗。平均研究持续时间为6.1年，其中包括半年一次的自主神经功能测定（ANX 3.0，ANSAR Medical Technologies，Inc.，宾夕法尼亚州费城）和年度心肌灌注SPECT研究（MPI）。有29％RANCD患者经历过MACE，而有46％NORANCD患者经历了MACE（p = 0.0105）。两组均具有异常副交感和交感（P＆S）措施和MACE的患者中，有MACE的患者共52例，而没有MACE的患者占17％（p =）0.0274）。在具有异常（P＆S）措施和MACE的患者中，MPI异常的占35％，而没有MACE的患者则占12％。 RANCD组的交感神经平衡（SB）较低，表明较高的相对副交感神经张力（已知具有心脏保护作用）。急性冠状动脉综合征发生率是NORANCD患者的4.5倍。在发生MACE的CD患者中，高SB发生率比MPI异常患者高。除了增加心肌血流量作为其建议的心绞痛缓解机制外，RAN还改善了P＆S措施，这是RAN改善结局的潜在新机制。

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