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首页> 美国卫生研究院文献>ACS Omega >One-Pot Synthesis of Carbon Nanodots in an OrganicMedium with Aggregation-Induced Emission Enhancement (AIEE): A Rationalefor Enzyme-Free Detection of Cholesterol
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One-Pot Synthesis of Carbon Nanodots in an OrganicMedium with Aggregation-Induced Emission Enhancement (AIEE): A Rationalefor Enzyme-Free Detection of Cholesterol

机译：一锅法合成有机碳纳米点具有聚集诱导排放增强（AIEE）的介质：基本原理用于胆固醇的无酶检测

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摘要

Addressing the limitations associated with the detection of cholesterol, we present a one-pot synthesis of a carbon nanodot (CD) in an organic medium (CDorg) from a novel bile acid hydrazone-based organogel. Interestingly, CDorg possesses the aggregation-induced emission enhancement (AIEE) phenomenon, which rationally aids in the “enzyme-free” detection of cholesterol through a fluorescence turn-on mechanism. On dilution of the THF/water mixture of CDorg with its poor solvent (water), a 9.8-fold enhancement in its photoluminescence (PL) emission is witnessed. Such an enhancement in PL emission is credited to the occurrence of molecular restrictions due to the formation of nanoaggregates of CDorg, thereby initiating a radiative pathway for exciton decay. Excitingly on adding cholesterol to CDorg, we observed a similar enhancement in its PL emission without the use of any cholesterol oxidase (ChOx) enzyme. The limit of detection and limit of quantification of cholesterol is found to be as low as 1.09 and 3.64 μM, respectively. Hence, this contribution highlights the enzyme-free fluorescence turn-on detection of cholesterol by a novel CD rationallydesigned to extend its applicability in an organic medium, where itis still considered a major restraint.
机译：为了解决与胆固醇检测相关的局限性，我们提出了从一锅胆汁酸基有机凝胶在有机介质（CDorg）中一锅合成碳纳米点（CD）的方法。有趣的是，CDorg具有聚集诱导的发射增强（AIEE）现象，该现象通过荧光开启机制合理地帮助胆固醇的“无酶”检测。将CDorg的THF /水混合物用不良溶剂（水）稀释后，其光致发光（PL）发射增强了9.8倍。 PL发射的这种增加归因于由于CDorg纳米聚集体的形成而导致的分子限制的发生，从而引发了激子衰减的辐射途径。令人兴奋的是，在不使用任何胆固醇氧化酶（ChOx）的情况下，将胆固醇添加到CDorg上，我们观察到PL排放量的增加类似。发现胆固醇的检出限和定量限分别低至1.09和3.64μM。因此，这一贡献突出了通过新型CD合理地检测胆固醇的无酶荧光开启检测旨在扩大其在有机介质中的适用性仍然被认为是主要的限制。

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