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首页> 美国卫生研究院文献>Infection and Immunity >Macrophage Cytophilic Antibody in Mice: Effect of Bacterial Lipopolysaccharide on the Uptake of Immunoglobulins by Mouse Peritoneal Cells
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Macrophage Cytophilic Antibody in Mice: Effect of Bacterial Lipopolysaccharide on the Uptake of Immunoglobulins by Mouse Peritoneal Cells

机译：小鼠巨噬细胞嗜细胞抗体：细菌脂多糖对小鼠腹膜细胞摄取免疫球蛋白的影响

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Injection of lipopolysaccharide from Escherichia coli intravenously into mice affected the ability of their peritoneal macrophages to adsorb antisheep erythrocyte cytophilic antibodies in vitro. After a single intravenous injection of lipopolysaccharide, the alteration in antibody uptake took the form of a triphasic response. An early evanescent increase in adsorptive capacity took place, which reached a maximum 5 min after injection and was followed immediately by a phase of depressed uptake of antibody. Enhancement of antibody uptake then increased to reach a maximum about 24 hr after injection, before declining slowly. The second enhancement phase was inhibited by prior immunization with E. coli or after multiple injections of lipopolysaccharide. Exposure of macrophages to lipopolysaccharide in vitro did not alter their capacity to take up cytophilic antibody. Changes in the capacity of macrophages and polymorphonuclear neutrophil leukocytes to adsorb opsonized erythrocytes were induced by injection of lipopolysaccharide and were similar to those induced with respect to the uptake of cytophilic antibodies by macrophages.
机译：将大肠杆菌中的脂多糖静脉内注射到小鼠体内，影响了其腹膜巨噬细胞在体外吸收抗绵羊红细胞嗜细胞抗体的能力。在单次静脉注射脂多糖后，抗体摄取的改变采取了三相反应的形式。吸附能力出现了早期消逝的增加，在注射后5分钟达到最大，随后紧接着是抗体摄取降低的阶段。抗体吸收的增强随后增加，直到注射后约24小时达到最大值，然后缓慢下降。第二增强阶段被事先用大肠杆菌免疫或多次注射脂多糖抑制。巨噬细胞在体外暴露于脂多糖并没有改变其摄取嗜细胞抗体的能力。巨噬细胞和多形核嗜中性白细胞吸附调理性红细胞的能力变化是通过注射脂多糖诱导的，与巨噬细胞摄取嗜细胞抗体引起的变化相似。

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