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首页> 美国卫生研究院文献>Microbiome >Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates
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Impact of intrapartum antimicrobial prophylaxis upon the intestinal microbiota and the prevalence of antibiotic resistance genes in vaginally delivered full-term neonates

机译：分娩期抗菌药物预防对阴道分娩足月新生儿肠道菌群和抗生素抗性基因流行的影响

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BackgroundDisturbances in the early establishment of the intestinal microbiota may produce important implications for the infant’s health and for the risk of disease later on. Different perinatal conditions may be affecting the development of the gut microbiota. Some of them, such as delivery mode or feeding habits, have been extensively assessed whereas others remain to be studied, being critical to identify their impact on the microbiota and, if any, to minimize it. Antibiotics are among the drugs most frequently used in early life, the use of intrapartum antimicrobial prophylaxis (IAP), present in over 30% of deliveries, being the most frequent source of exposure. However, our knowledge on the effects of IAP on the microbiota establishment is still limited. The aim of the present work was to evaluate the impact of IAP investigating a cohort of 40 full-term vaginally delivered infants born after an uncomplicated pregnancy, 18 of which were born from mothers receiving IAP.
机译：背景肠道菌群早期建立的紊乱可能对婴儿的健康和以后的疾病风险产生重要影响。不同的围产期条件可能会影响肠道菌群的发育。其中一些，例如分娩方式或进食习惯，已经得到了广泛的评估，而另一些则有待研究，这对于确定其对微生物的影响，以及最小化微生物的影响至关重要。抗生素是生命早期最常用的药物之一，超过30％的分娩中使用了产前抗微生物药物（IAP），是最常见的接触源。但是，我们对IAP对微生物群建立的影响的认识仍然有限。本研究的目的是评估IAP对40例无并发症妊娠后足月经阴道分娩的婴儿进行研究的影响，其中18例来自接受IAP的母亲。

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