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首页> 美国卫生研究院文献>Infection and Immunity >The shdA Gene Is Restricted to Serotypes of Salmonella enterica Subspecies I and Contributes to Efficient and Prolonged Fecal Shedding
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The shdA Gene Is Restricted to Serotypes of Salmonella enterica Subspecies I and Contributes to Efficient and Prolonged Fecal Shedding

机译：shdA基因仅限于肠炎沙门氏菌亚种I的血清型并有助于有效和长时间的粪便脱落

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摘要

Little is known about factors which enable Salmonella serotypes to circulate within populations of livestock and domestic fowl. We have identified a DNA region which is present in Salmonella serotypes commonly isolated from livestock and domestic fowl (S. enterica subspecies I) but absent from reptile-associated Salmonella serotypes (S. bongori and S. enterica subspecies II to VII). This DNA region was cloned from Salmonella serotype Typhimurium and sequence analysis revealed the presence of a 6,105-bp open reading frame, designated shdA, whose product's deduced amino acid sequence displayed homology to that of AIDA-I from diarrheagenic Escherichia coli, MisL of serotype Typhimurium, and IcsA of Shigella flexneri. The shdA gene was located adjacent to xseA at 52 min, in a 30-kb DNA region which is not present in Escherichia coli K-12. A serotype Typhimurium shdA mutant was shed with the feces in reduced numbers and for a shorter period of time compared to its isogenic parent. A possible role for the shdA gene during the expansion in host range of S. enterica subspecies I to include warm-blooded vertebrates is discussed.
机译：关于使沙门氏菌血清型能够在牲畜和家禽种群中传播的因素知之甚少。我们已经鉴定出存在于通常从牲畜和家禽中分离出的沙门氏菌血清型中存在的一个DNA区（S. enterica亚种I，但与爬行动物相关的沙门氏菌血清型（S. bongori和S. enterica亚种II至VII）中不存在）。从沙门氏菌血清型鼠伤寒杆菌中克隆了该DNA区，序列分析显示存在一个6,105 bp的开放阅读框，称为shdA，其推导的氨基酸序列与腹泻性大肠杆菌AIDA-I的同源性，即血清型鼠伤菌MisL。 ，以及志贺志贺氏菌的IcsA。 shdA基因在30分钟时位于xseA的附近，位于30 kb的DNA区域，该区域在大肠杆菌K-12中不存在。与同基因的亲本相比，血清型鼠伤寒shdA突变体的粪便数量减少，并且排泄时间较短。讨论了shdA基因在肠球菌S亚种I宿主范围扩展中包括温血脊椎动物的可能作用。

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