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首页> 美国卫生研究院文献>Infection and Immunity >Coxiella burnetii Isolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever
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Coxiella burnetii Isolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever

机译：柯氏杆菌分离株在急性Q发热的小鼠和豚鼠模型中引起基因组特异性毒力

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摘要

Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and pathological responses to infection with phase I C. burnetii isolates from the following four genomic groups were evaluated in immunocompetent and immunocompromised mice and in guinea pig infection models: group I (Nine Mile, African, and Ohio), group IV (Priscilla and P), group V (G and S), and group VI (Dugway). Isolates from all of the groups produced disease in the SCID mouse model, and genogroup-consistent trends were noted in cytokine production in response to infection in the immunocompetent-mouse model. Guinea pigs developed severe acute disease when aerosol challenged with group I isolates, mild to moderate acute disease in response to group V isolates, and no acute disease when infected with group IV and VI isolates. C. burnetii isolates have a range of disease potentials; isolates within the same genomic group cause similar pathological responses, and there is a clear distinction in strain virulence between these genomic groups.
机译：Q热是专一性的细胞内细菌伯氏杆菌引起的一种人畜共患疾病。 Q发热的人可能会出现急性流感样疾病，肺炎和/或慢性肝炎或心内膜炎。各种标记物显示出急性和慢性人类疾病分离株之间显着的系统发育分离和聚集。在免疫活性和免疫功能低下的小鼠以及豚鼠感染模型中评估了以下四个基因组群对阶段I. Burnetii分离株感染的临床和病理反应：第一组（九英里，非洲和俄亥俄州），第四组（普里西利亚）和P），第V组（G和S）和第VI组（Dugway）。来自所有组的分离物在SCID小鼠模型中产生疾病，并且在免疫功能小鼠模型中注意到细胞因子产生对感染的反应中基因组一致的趋势。当用I组分离株进行气雾剂攻击时，豚鼠会发展为严重的急性疾病；对V组分离株有轻度至中度的急性疾病；而当感染IV组和VI组分离株时则无急性疾病。伯氏梭状芽胞杆菌分离物具有多种潜在疾病；同一基因组中的分离株引起相似的病理反应，并且这些基因组之间的毒力有明显区别。

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