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首页> 美国卫生研究院文献>Materials >Collagen Fibrils in Skin Orient in the Direction of Applied Uniaxial Load in Proportion to Stress while Exhibiting Differential Strains around Hair Follicles
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Collagen Fibrils in Skin Orient in the Direction of Applied Uniaxial Load in Proportion to Stress while Exhibiting Differential Strains around Hair Follicles

机译：皮肤中的胶原蛋白纤维在单轴载荷的方向上与应力成比例同时在毛囊周围表现出不同的应变

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We determined inhomogeneity of strains around discontinuities as well as changes in orientation of collagen fibrils under applied load in skin. Second Harmonic Generation (SHG) images of collagen fibrils were obtained at different strain magnitudes. Changes in collagen orientation were analyzed using Fast Fourier Transforms (FFT) while strain inhomogeneity was determined at different distances from hair follicles using Digital Image Correlation (DIC). A parameter, defined as the Collagen Orientation Index (COI), is introduced that accounts for the increasingly ellipsoidal nature of the FFT amplitude images upon loading. We show that the COI demonstrates two distinct mechanical regimes, one at low strains (0%, 2.5%, 5% strain) in which randomly oriented collagen fibrils align in the direction of applied deformation. In the second regime, beginning at 5% strain, collagen fibrils elongate in response to applied deformation. Furthermore, the COI is also found to be linearly correlated with the applied stress indicating that collagen fibrils orient to take the applied load. DIC results indicated that major principal strains were found to increase with increased load at all locations. In contrast, minimum principal strain was dependent on distance from hair follicles. These findings are significant because global and local changes in collagen deformations are expected to be changed by disease, and could affect stem cell populations surrounding hair follicles, including mesenchymal stem cells within the outer root sheath.
机译：我们确定了不连续周围的菌株的不均匀性，以及在皮肤上施加负荷下胶原纤维的取向变化。在不同的应变强度下获得了胶原纤维的二次谐波生成（SHG）图像。使用快速傅里叶变换（FFT）分析胶原蛋白取向的变化，同时使用数字图像相关（DIC）在距毛囊不同距离处确定菌株不均匀性。引入了一个定义为胶原蛋白定向指数（COI）的参数，该参数说明了加载后FFT振幅图像的椭圆性越来越强的特点。我们表明，COI表现出两种不同的机械状态，一种处于低应变（0％，2.5％，5％应变），其中随机取向的胶原纤维在应用的变形方向上对齐。在第二种方案中，从5％应变开始，胶原纤维响应所施加的变形而伸长。此外，还发现COI与所施加的应力线性相关，表明胶原原纤维倾向于承担所施加的负荷。 DIC结果表明，在所有位置，主要主应变随载荷增加而增加。相反，最小主应变取决于与毛囊的距离。这些发现意义重大，因为胶原蛋白变形的整体和局部变化预计会因疾病而改变，并且可能影响毛囊周围的干细胞种群，包括外根鞘内的间充质干细胞。

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