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首页> 美国卫生研究院文献>The Indian Journal of Surgery >Synchronous Rectal and Gastric Cancer in a Fighter Pilot: Aeromedical Concerns
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Synchronous Rectal and Gastric Cancer in a Fighter Pilot: Aeromedical Concerns

机译：战斗机飞行员中的同步性直肠癌和胃癌：航空医学问题

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Synchronous cancer of the stomach and rectum is very rare. In a special population of pilots, especially fighter pilots, synchronous rectal and gastric cancer is much more uncommon. We herein report a case of synchronous carcinoma of the rectum and stomach. The patient was a 44-year-old male fighter pilot who complained with bloody stool and altered bowel habits. He was diagnosed with hereditary nonpolyposis colorectal cancer with a definite family history, and subsequently he underwent simultaneous low anterior resection and distal gastrectomy with D2 lymphadenectomy. Postoperative pathologic assessment showed a poorly differentiated gastric adenocarcinoma with signet ring cell components (pT2N1M0; stage IIb) and a moderately differentiated rectal adenocarcinoma with myxoid components (pT3N0M0; stage IIa). Both tumors showed positive expression of p53, Ki-67, VEGF, carcinoembryonic antigen, MRP, TS, P-gp, and TopoII, and negative expression of c-erbB2, CD34, CD31, D2-40, S-100, FVIII, MLH1, MSH2, and MSH6 oncoproteins. Six cycles of XELOX chemotherapy and 50 Gy/25 f radiotherapy were delivered postoperatively. Now, he has returned to his work under medical observation for about 6 months. From this patient’s diagnosis and treatment, we think that the gene screening should be used in pilot selection. According to the result of gene screening, we can give pertinence examinations to the target organ of genes. It is very necessary for pilots to keep keen vigilance at gastrointestinal tumors because they have to face many high-risk factors in working. As to pilots, the selection of operation should be individualized.
机译：胃和直肠的同步癌非常罕见。在特殊的飞行员群体中，尤其是战斗机飞行员中，同步性直肠癌和胃癌很少见。我们在此报告了直肠和胃同步癌的病例。该患者是一名44岁的男性战斗机飞行员，抱怨粪便带血和排便习惯改变。他被确诊为遗传性非息肉性结直肠癌，具有明确的家族病史，随后他同时接受了低位前切除术和D2淋巴结清扫术同时进行了远端胃切除术。术后病理评估显示，低分化的胃腺癌伴有印戒细胞成分（pT2N1M0； IIb期）和中度分化的直肠腺癌伴有类胶体成分（pT3N0M0； IIa期）。两种肿瘤均显示p53，Ki-67，VEGF，癌胚抗原，MRP，TS，P-gp和TopoII阳性表达，而c-erbB2，CD34，CD31，D2-40，S-100，FVIII， MLH1，MSH2和MSH6癌蛋白。术后进行了六个周期的XELOX化疗和50Gy / 25f放疗。现在，他已经在医学观察下重返工作约6个月。从该患者的诊断和治疗来看，我们认为基因筛选应用于飞行员选择。根据基因筛选的结果，我们可以对目标基因进行相关性检查。飞行员必须非常警惕胃肠道肿瘤，因为他们在工作中必须面对许多高风险因素。对于飞行员而言，操作选择应个性化。

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