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首页> 美国卫生研究院文献>Medicina Oral Patologa Oral y Ciruga Bucal >Management of dental extraction in patients with Haemophilia A and B: A report of 58 extractions
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Management of dental extraction in patients with Haemophilia A and B: A report of 58 extractions

机译：冠心病患者拔牙的管理甲型和乙型血友病：58种提取物的报告

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Objectives: Patients with inherited bleeding disorders are at high risk of bleeding following oral surgery and present challenges to the oral surgeons. Aim of this study was to report our experience in dental extraction in patients exhibiting Haemophilia A and B between 2007 and 2012. Patient and Methods: 58 dental extractions in 15 patients during 19 interventions were performed. Replacement therapy with recombinant and plasma-derived factor VIII and IX was applied systematically in combination with antifibrinolytic treatment and local haemostatic measures. The following data were recorded: type of surgery, applied local haemostatic measures, general substitution, systemic antifibrinolytic agents and occurrence of postoperative bleeding complications. Results: Two patients presented postoperative bleeding. One had secondary bleeding requiring additional injection of factor concentrates. The other one presented epistaxis which was managed conservatively with a nasal tamponade. Conclusions: Excellent haemostasis is achievable after dental extractions in patients with Haemophilia A and B by following a protocol using defined pre- and postoperative doses of factor concentrates in combination with haemostatic measures. > Key words:Antifibrinolytic treatment, dental extraction, Haemophilia, inherited bleeding disorders, local haemostatic measures.
机译：目的：患有遗传性出血性疾病的患者在口腔手术后出血的风险很高，并且给口腔外科医师带来了挑战。这项研究的目的是报告我们在2007年至2012年之间对患有A和B型血友病的患者进行拔牙的经验。患者与方法：在19项干预措施中，对15例患者进行了58次拔牙。结合重组抗血浆蛋白治疗和局部止血措施，系统地应用了重组和血浆衍生的凝血因子VIII和IX进行替代治疗。记录以下数据：手术类型，采取的局部止血措施，一般替代，全身性抗纤溶剂和术后出血并发症的发生。结果：两名患者出现术后出血。一个患有继发性出血，需要额外注射浓缩因子。另一个出现鼻epi，保守地用鼻塞填塞。结论：通过遵循定义的术前和术后剂量的因子浓缩物结合止血措施的协议，对A和B血友病患者进行牙科拔牙后可实现出色的止血效果。 >关键词：抗纤溶治疗，拔牙，血友病，遗传性出血病，局部止血措施。

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