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Lack of correlation between the effects of cortisone on mouse spleen plaque-forming cells and circulating anti-sheep red blood cell haemolysins

机译:可的松对小鼠脾脏斑块形成细胞的作用与循环抗绵羊红细胞溶血素之间缺乏相关性

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摘要

The effect of 5.5 mg of cortisone acetate given to adult mice 1 day prior to the injection of 4 × 108 sheep erythrocytes was studied. This drug is able to suppress more than 95 per cent of splenic plaque-forming cells (PFC) compared with immunized animals not treated with cortisone. However, the anti-sheep red cell haemolytic titre in the blood was not affected. Several hypotheses to explain this paradox were tested experimentally.Plaque-forming cells in the bone-marrow of cortisone-treated mice, instead of being suppressed, increased to more than ten times their number compared with the controlled animals.
机译:研究了在注射4×10 8 绵羊红细胞前1天给成年小鼠5.5 mg醋酸可的松的作用。与未经可的松治疗的免疫动物相比,该药物能够抑制超过95%的脾脏斑块形成细胞(PFC)。但是,血液中的抗绵羊红细胞溶血滴度没有受到影响。实验证明了解释这一悖论的几种假设。可的松治疗小鼠的骨髓中形成斑块的细胞,而不是被抑制,增加了其数量,是对照动物的十倍。

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