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首页> 美国卫生研究院文献>Materials >Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium
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Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

机译：微电弧氧化增强了超细晶纯钛的血液相容性

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Ultrafine-grained pure titanium prepared by equal-channel angular pressing has favorable mechanical performance and does not contain alloy elements that are toxic to the human body. It has potential clinical value in applications such as cardiac valve prostheses, vascular stents, and hip prostheses. To overcome the material’s inherent thrombogenicity, surface-coating modification is a crucial pathway to enhancing blood compatibility. An electrolyte solution of sodium silicate + sodium polyphosphate + calcium acetate and the micro-arc oxidation (MAO) technique were employed for in situ oxidation of an ultrafine-grained pure titanium surface. A porous coating with anatase- and rutile-phase TiO2 was generated and wettability and blood compatibility were examined. The results showed that, in comparison with ultrafine-grained pure titanium substrate, the MAO coating had a rougher surface, smaller contact angles for distilled water and higher surface energy. MAO modification effectively reduced the hemolysis rate; extended the dynamic coagulation time, prothrombin time (PT), and activated partial thromboplastin time (APTT); reduced the amount of platelet adhesion and the degree of deformation; and enhanced blood compatibility. In particular, the sample with an oxidation time of 9 min possessed the highest surface energy, largest PT and APTT values, smallest hemolysis rate, less platelet adhesion, a lesser degree of deformation, and more favorable blood compatibility. The MAO method can significantly enhance the blood compatibility of ultrafine-grained pure titanium, increasing its potential for practical applications.
机译：通过等通道角压制得的超细晶粒纯钛具有良好的机械性能，并且不含对人体有毒的合金元素。它在诸如心脏瓣膜假体，血管支架和髋关节假体的应用中具有潜在的临床价值。为了克服材料固有的血栓形成性，表面涂层改性是增强血液相容性的关键途径。采用硅酸钠+聚磷酸钠+醋酸钙的电解质溶液和微弧氧化（MAO）技术对超细晶粒的纯钛表面进行原位氧化。生成了具有锐钛矿相和金红石相TiO2的多孔涂层，并检查了润湿性和血液相容性。结果表明，与超细颗粒纯钛基体相比，MAO涂层的表面更粗糙，与蒸馏水的接触角更小，表面能更高。 MAO修饰有效降低了溶血率；延长了动态凝血时间，凝血酶原时间（PT）和活化的部分凝血活酶时间（APTT）；减少血小板粘附量和变形程度；增强血液相容性。尤其是，氧化时间为9分钟的样品具有最高的表面能，最大的PT和APTT值，最小的溶血速率，较少的血小板粘附，较小的变形度和更有利的血液相容性。 MAO方法可以显着增强超细颗粒纯钛的血液相容性，从而增加其在实际应用中的潜力。

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