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首页> 美国卫生研究院文献>Materials >Zirconia/Hydroxyapatite Composites Synthesized Via Sol-Gel: Influence of Hydroxyapatite Content and Heating on Their Biological Properties
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Zirconia/Hydroxyapatite Composites Synthesized Via Sol-Gel: Influence of Hydroxyapatite Content and Heating on Their Biological Properties

机译：溶胶-凝胶法合成氧化锆/羟基磷灰石复合材料：羟基磷灰石含量和加热对其生物学特性的影响

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Zirconia (ZrO2) and zirconia-based glasses and ceramics are materials proposed for use in the dental and orthopedic fields. In this work, ZrO2 glass was modified by adding different amounts of bioactive and biocompatible hydroxyapatite (HAp). ZrO2/HAp composites were synthesized via the sol-gel method and heated to different temperatures to induce modifications of their chemical structure, as ascertained by Fourier transform infrared spectroscopy (FTIR) analysis. The aim was to investigate the effect of both HAp content and heating on the biological performances of ZrO2. The materials’ bioactivity was studied by soaking samples in a simulated body fluid (SBF). FTIR and scanning electron microscopy (SEM)) analyses carried out after exposure to SBF showed that all materials are bioactive, i.e., they are able to form a hydroxyapatite layer on their surface. Moreover, the samples were soaked in a solution containing bovine serum albumin (BSA). FTIR analysis proved that the synthesized materials are able to adsorb the blood protein, the first step of cell adhesion. WST-8 ([2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt]) assay showed that no cytotoxicity effects were induced by the materials’ extract. However, the results proved that bioactivity increases with both the HAp content and the temperature used for the thermal treatment, whereas biocompatibility increases with heating but is not affected by the HAp content.
机译：氧化锆（ZrO2）和基于氧化锆的玻璃和陶瓷是被提议用于牙科和整形外科领域的材料。在这项工作中，通过添加不同数量的生物活性和生物相容性羟基磷灰石（HAp）来改性ZrO2玻璃。通过傅里叶变换红外光谱（FTIR）分析确定，通过溶胶-凝胶法合成ZrO2 / HAp复合材料并加热至不同温度以诱导其化学结构的改变。目的是研究HAp含量和加热对ZrO2生物学性能的影响。通过将样品浸泡在模拟体液（SBF）中来研究材料的生物活性。暴露于SBF后进行的FTIR和扫描电子显微镜（SEM）分析表明，所有材料均具有生物活性，即它们能够在其表面上形成羟基磷灰石层。此外，将样品浸泡在含有牛血清白蛋白（BSA）的溶液中。 FTIR分析证明合成的材料能够吸附血液蛋白，这是细胞粘附的第一步。 WST-8（[2-（2-甲氧基-4-硝基苯基）-3-（4-硝基苯基）-5-（2,4-二磺基苯基）-2H-四唑鎓，单钠盐]）检测表明没有细胞毒性作用由材料的提取物诱导。然而，结果证明生物活性随HAp含量和用于热处理的温度一起增加，而生物相容性随加热而增加，但不受HAp含量影响。

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