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首页> 美国卫生研究院文献>Indian Journal of Otolaryngology and Head Neck Surgery >A prospective randomised study to assess the efficacy of differenct medications for relief of post-operative nasal obstruction
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A prospective randomised study to assess the efficacy of differenct medications for relief of post-operative nasal obstruction

机译：一项前瞻性随机研究评估不同药物缓解术后鼻塞的疗效

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摘要

Surgery to the nasal septum and to the turbinates constitutes a significant part of the workload of an otolaryngologist. The patient invariably experiences short-term nasal obstruction following such surgery and different medications are commonly used to relieve this and to promote a sense of airway patency. However the efficacy of topical and systemic medication, given in the post-operative period is hot well documented. A prospective randomized trial was therefore undertaken to compare the efficacy of a topically applied vasoconstrictor and an anticholinergic agent in reducing the sensation of airway obstruction in the first week following simple nasal airway surgery. 0.5% Ephedrine hydrochloride nasal drops, Pseudoephedrine tablets and a combination of the two were compared to a control group who received no treatment. Eighty patients were randomised into four groups and nasal patency assessed by patients using a visual analogue sacle (VAS). When compared to the control group both medications were effective in relieving nasal congestion but a combination of topical and systemic therapy, given together, was superior to either agent used alone. The results achieved were independent of the seniority of the surgeon undertaking the operation.
机译：鼻中隔和鼻甲手术是耳鼻喉科医生工作量的重要组成部分。患者在进行此类手术后总是会出现短期鼻塞，通常使用不同的药物来缓解这种情况并增强呼吸道通畅感。然而，在术后期间给予局部和全身药物治疗的疗效已被大量文献证明。因此，进行了一项前瞻性随机试验，以比较简单鼻腔手术后第一周局部应用血管收缩药和抗胆碱能药在减少气道阻塞感觉方面的功效。将0.5％的盐酸麻黄碱滴鼻剂，伪麻黄碱片和两者的组合与未接受治疗的对照组进行比较。将80例患者随机分为四组，并由患者使用视觉模拟囊（VAS）评估鼻腔通畅性。与对照组相比，两种药物均可有效缓解鼻塞，但局部和全身治疗相结合，优于单独使用两种药物。所获得的结果与进行手术的外科医生的资历无关。

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