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Reduction of spontaneous autoimmune diabetes in diabetes-prone BB rats with the novel immunosuppressant fusidic acid. Effect on T-cell proliferation and production of interferon-gamma.

机译：用新型免疫抑制剂夫西地酸减少易患糖尿病的BB大鼠的自发性自身免疫性糖尿病。对T细胞增殖和γ干扰素产生的影响。

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摘要

Diabetes-prone (DP) BB rats spontaneously develop a hyperglycaemic condition which closely resembles human insulin-dependent diabetes mellitus (IDDM), both in terms of clinical and histological features. The incidence of IDDM was significantly reduced when these animals were treated with 2 or 4 mg fusidic acid (FA)/day i.m. from day 30 to day 120 of age. In addition, the mean insulitis score was significantly diminished in the animals treated with FA compared to both vehicle-treated and untreated controls. Finally, 2 mg/day of FA i.m. prevented cell proliferation and interferon-gamma secretion from peripheral blood mononuclear cells upon ex vivo stimulation with concanavalin A. The capacity of FA to substantially reduce the incidence of autoimmune diabetes in a well-known animal model of human IDDM supports previous observations regarding the immunosuppressive properties of FA and its potential use in the treatment of human autoimmune diabetes.

机译：糖尿病倾向（DP）BB大鼠自发发展为高血糖症，无论是在临床还是在组织学方面，它都非常类似于人胰岛素依赖性糖尿病（IDDM）。当这些动物每天2或4 mg夫西地酸（FA）处理后，IDDM的发生率显着降低。从30岁到120岁。另外，与用赋形剂治疗的和未治疗的对照相比，用FA治疗的动物的平均炎性耳炎评分显着降低。最后，每天2 mg FA。预防伴刀豆球蛋白A离体刺激后外周血单核细胞的细胞增殖和干扰素-γ分泌。在人IDDM的著名动物模型中，FA具有显着降低自身免疫性糖尿病发病率的能力，支持了先前有关免疫抑制特性的观察FA及其在治疗人类自身免疫性糖尿病中的潜在用途。

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期刊名称 Immunology
作者
F Nicoletti; R Di Marco; S Morrone; P Zaccone; D Lembo; S Grasso; A Santoni; P L Meroni; K Bendtzen;
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作者单位

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年(卷),期 1994(81),2
年度 1994
页码 317–321
总页数 5
原文格式 PDF
正文语种
中图分类免疫学;
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专利

1. Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture. [J] . Zipris D, Leif J, Deluca D, Cellular and molecular biology . 2001,第1期

机译：易患糖尿病的BB / Wor大鼠的胸腺胎儿胸腺不能在器官培养物中生成成熟的ART2 + T细胞。
2. Potential mechanisms explaining why hydrolyzed casein-based diets outclass single amino acid-based diets in the prevention of autoimmune diabetes in diabetes-prone BB rats [J] . VisserJ.T.J., BosN.A., HarthoornL.F., Diabetes/metabolism research and reviews . 2012,第6期

机译：解释为什么在容易患糖尿病的BB大鼠中，以酪蛋白为基础的饮食在预防自身免疫性糖尿病方面为何优于基于单氨基酸的饮食
3. Prolonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone rats. [J] . Brugman S, Visser JT, Hillebrands JL, Diabetes/metabolism research and reviews . 2009,第4期

机译：长时间纯母乳喂养可降低易发生生物繁殖的糖尿病大鼠自身免疫性糖尿病的发生率，并增加调节性T细胞频率。
4. Synthesis and in vitro effect of peptide-conjugates from 38 kDa protein of M.tuberculosis on T-cell proliferation and IFN-y production [C] . Szilvia Bosze, Nadia Caccamo, Gabor Mezo International Peptide Symposium;European Peptide Symposium . 2005

机译：肽 - 缀合物从38 kDa蛋白的肽 - 缀合物对T细胞增殖和IFN-Y生产的合成及体外效应
5. Decreased IFN-gamma message by pancreatic islet-infiltrating leukocytes is a common feature of different treatments that protect against autoimmune diabetes in the BB rat [D] . El-Sheikh, Amr Abdelhamid Farag. 1998

机译：胰岛浸润性白细胞减少的IFN-γ信息是防止BB大鼠自身免疫性糖尿病的不同治疗方法的共同特点
6. Cytotoxic T-cell precursors with low-level CD8 in the diabetes-prone Biobreeding rat: implications for generation of an autoimmune T-cell repertoire. [O] . D Bellgrau, A C Lagarde 1990

机译：易患糖尿病的生物育种大鼠中具有低水平CD8的细胞毒性T细胞前体：对自身免疫性T细胞库生成的影响。
7. Prevention of Spontaneous Autoimmune Diabetes in Diabetes-Prone BB Rats by Prophylactic Treatment with Antirat Interferon- Antibody [O] . F. Nicoletti 1997

机译：通过预防性治疗用抗真菌干扰素 - 抗体预防糖尿病 - 易患BB大鼠的自发自身免疫糖尿病

Reduction of spontaneous autoimmune diabetes in diabetes-prone BB rats with the novel immunosuppressant fusidic acid. Effect on T-cell proliferation and production of interferon-gamma.

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