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首页> 美国卫生研究院文献>Materials >The Effect of Surface Modification of Ti13Zr13Nb Alloy on Adhesion of Antibiotic and Nanosilver-Loaded Bone Cement Coatings Dedicated for Application as Spacers
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The Effect of Surface Modification of Ti13Zr13Nb Alloy on Adhesion of Antibiotic and Nanosilver-Loaded Bone Cement Coatings Dedicated for Application as Spacers

机译：Ti13Zr13Nb合金的表面改性对抗生素和纳米银负载骨水泥涂层的附着力的影响

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Spacers, in terms of instruments used in revision surgery for the local treatment of postoperative infection, are usually made of metal rod covered by antibiotic-loaded bone cement. One of the main limitations of this temporary implant is the debonding effect of metal–bone cement interface, leading to aseptic loosening. Material selection, as well as surface treatment, should be evaluated in order to minimize the risk of fraction and improve the implant-cement fixation the appropriate manufacturing. In this study, Ti13Zr13Nb alloys that were prepared by Selective Laser Melting and surface treated were coated with bone cement loaded with either gentamicin or nanosilver, and the effects of such alloy modifications were investigated. The SLM-made specimens of Ti13Zr13Nb were surface treated by sandblasting, etching, or grounding. For each treatment, Scanning Electron Microscope (SEM), contact profilometer, optical tensiometer, and nano-test technique carried out microstructure characterization and surface analysis. The three types of bone cement i.e., pure, containing gentamicin and doped with nanosilver were applied to alloy surfaces and assessed for cement cohesion and its adhesion to the surface by nanoscratch test and pull-off. Next, the inhibition of bacterial growth and cytocompatibility of specimens were investigated by the Bauer-Kirby test and MTS assay respectively. The results of each test were compared to the two control groups, consisting of commercially available Ti13Zr13Nb and untreated SLM-made specimens. The highest adhesion bone cement to the titanium alloy was obtained for specimens with high nanohardness and roughness. However, no explicit relation of adhesion strength with wettability and surface energy of alloy was observed. Sandblasting or etching were the best alloys treatments in terms of the adhesion of either pure or modified bone cements. Antibacterial additives for bone cement affected its properties. Gentamicin and nanosilver allowed for adequate anti-bacterial protection while maintaining the overall biocompatibility of obtained spacers. However, they had different effects on the cement’s adhesive capacity or its own cohesion. Furthermore, the addition of silver nanoparticles improved the nanomechanical properties of bone cements. Surface treatment and method of fabrication of titanium affected surface parameters that had a significant impact on cement-titanium fixation.
机译：就翻修手术中用于局部治疗术后感染的器械而言，垫片通常由覆盖有抗生素的骨水泥覆盖的金属棒制成。这种临时植入物的主要限制之一是金属-骨水泥界面的脱粘作用，导致无菌性松动。应评估材料的选择以及表面处理，以最大程度地降低碎裂风险，并在适当的制造过程中改善植入物-水泥的固定。在这项研究中，通过选择性激光熔化制备并经过表面处理的Ti13Zr13Nb合金被负载庆大霉素或纳米银的骨水泥覆盖，并研究了这种合金改性的效果。用喷砂，蚀刻或接地对SLM制得的Ti13Zr13Nb试样进行表面处理。对于每种处理，使用扫描电子显微镜（SEM），接触轮廓仪，光学张力仪和纳米测试技术进行了微结构表征和表面分析。将三种类型的骨水泥，即纯的，含有庆大霉素并掺杂有纳米银的骨水泥应用于合金表面，并通过纳米划痕试验和拉脱法评估水泥的内聚力及其对表面的附着力。接下来，分别通过Bauer-Kirby试验和MTS试验研究了样品对细菌生长和细胞相容性的抑制作用。将每个测试的结果与两个对照组进行比较，这两个对照组由市售的Ti13Zr13Nb和未经处理的SLM制得的样品组成。对于具有高纳米硬度和粗糙度的样品，获得了对钛合金的最高粘附性骨水泥。然而，没有观察到粘附强度与合金的润湿性和表面能的明确关系。就纯骨水泥或改性骨水泥的附着力而言，喷砂或蚀刻是最好的合金处理方法。用于骨水泥的抗菌添加剂影响其性能。庆大霉素和纳米银可提供足够的抗菌保护，同时保持所获得间隔基的整体生物相容性。但是，它们对水泥的粘合能力或自身粘结力有不同的影响。此外，银纳米颗粒的添加改善了骨水泥的纳米机械性能。钛的表面处理和制造方法影响了对水泥-钛固定具有重大影响的表面参数。

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