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Development and Characterization of Composites Consisting of Calcium Phosphate Cements and Mesoporous Bioactive Glass for Extrusion-Based Fabrication

机译：磷酸钙水泥与介孔生物活性玻璃复合材料的制备及表征

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Calcium phosphate cements (CPC) and mesoporous bioactive glasses (MBG) are two degradable biomaterial groups widely under investigation concerning their applicability to treat bone defects. MBG-CPC composites were recently shown to possess enhanced degradation properties in comparison to pure CPC. In addition, modification of MBG allows an easy incorporation of therapeutically effective ions. Additive manufacturing of such composites enables the fabrication of patient-specific geometries with further improved degradation behavior due to control over macroporosity. In this study, we developed composites prepared from a non-aqueous carrier-liquid (cl) based CPC paste and MBG particles suitable for extrusion-based additive manufacturing (3D plotting). CPC with the addition of up to 10 wt % MBG were processible by adjusting the amount of cl. Scaffolds consisting of a 4, 6 and 8%-MBG-CPC composite were successfully manufactured by 3D plotting. While mechanically characterization of the scaffolds showed an influence of the MBG, no changes of microstructure were observed. During degradation of the composite, the release of Ca2+ and Sr2+ ions could be controlled by the MBG composition and plotted scaffolds with macropores showed a significant higher release than bulk samples of comparable mass. These findings demonstrate a high flexibility regarding ion release of the developed composites and suggest utilizing the drug binding capacities of MBG as a prospective delivery system for biologically active proteins.
机译：磷酸钙水泥（CPC）和中孔生物活性玻璃（MBG）是两个可降解的生物材料，正在研究中，它们可用于治疗骨缺损。与纯CPC相比，MBG-CPC复合材料最近显示出增强的降解性能。另外，MBG的修饰允许容易结合治疗有效离子。由于控制大孔，这种复合材料的增材制造能够制造具有特定改善的降解行为的患者特定几何形状。在这项研究中，我们开发了由非水性载液（cl）的CPC糊剂和MBG颗粒制成的复合材料，这些颗粒适用于基于挤压的增材制造（3D绘图）。通过调节cl的量，可以添加最高10 wt％MBG的CPC。通过3D绘图成功制造了包含4、6和8％-MBG-CPC复合材料的支架。虽然支架的机械表征显示了MBG的影响，但未观察到微观结构的变化。在复合材料降解过程中，MBG组成可以控制Ca 2 + 和Sr 2 + 离子的释放，并且带有大孔的标绘支架比大体积释放出明显更高的释放。质量相当的样品。这些发现表明，对于已开发的复合材料的离子释放具有高度的灵活性，并建议利用MBG的药物结合能力作为生物活性蛋白的预期传递系统。

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