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首页> 美国卫生研究院文献>Materials >Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composite β-TCP—Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats
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Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composite β-TCP—Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats

机译：掺入β-TCP作为增强复合β-TCP-无碱生物活性玻璃骨移植物再生潜能的策略。大鼠实验研究

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摘要

The present work aims at evaluating the potential gains derived from partially replacing calcium in resorbable β-tricalcium phosphate (β-TCP) by two different molar percentages of strontium (5, 10) and zinc (1, 2), concomitantly with a fixed molar percentage (0.5) of manganese. Synthetic granular composite bone filling grafts consisting of doped β-TCP and an alkali-free bioactive glass were prepared and implanted in ~4 mm diameter bone defects drilled in the calvaria of Wistar rats used as animal models. The animals were sacrificed after 9 weeks of implantation and the calvaria was excised. Non-manipulated bone was used as positive control, while empty defects were used as a negative control group. The von Kossa staining revealed an enhanced new bone formation with increasing doping levels, supporting the therapeutic effects exerted by the doping elements. The percentage of newly formed bone was similar when the defects were filled with autologous bone, BG (previous results) or 3TCP2/7BG, which indicates that the latter two are excellent candidates for replacement of autologous bone as bone regeneration material. This finding confirms that doping with suitable doses of therapeutic ions is a good strategy towards transposing the bone graft materials to biomedical applications in humans.
机译：本工作旨在评估通过用两种不同摩尔百分比的锶（5、10）和锌（1、2）以及固定摩尔数部分替代可吸收β-磷酸三钙（β-TCP）中的钙所获得的潜在收益锰的百分比（0.5）。制备了由掺杂的β-TCP和无碱生物活性玻璃组成的合成颗粒复合骨填充移植物，并将其植入约4 mm直径的骨骼缺损中，该骨骼缺损在Wistar大鼠的颅盖中用作动物模型。植入9周后处死动物并切除颅盖。未操纵的骨被用作阳性对照组，而空缺缺损被用作阴性对照组。冯·科萨（von Kossa）染色显示，随着掺杂水平的提高，新的骨骼形成得以增强，从而支持了掺杂元素所产生的治疗效果。当缺损充满自体骨，BG（以前的结果）或3TCP2 / 7BG时，新形成的骨的百分比相似，这表明后两者是替代自体骨作为骨再生材料的优秀候选者。这一发现证实，用适当剂量的治疗离子进行掺杂是将骨移植材料转移到人类生物医学应用中的好策略。

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