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首页> 美国卫生研究院文献>Materials >Geometry Effects of Axisymmetric Flow-Focusing Microchannels for Single Cell Encapsulation
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Geometry Effects of Axisymmetric Flow-Focusing Microchannels for Single Cell Encapsulation

机译：轴对称流聚焦微通道的单细胞封装的几何效应。

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Cell microencapsulation is a promising technique to protect living cells in biomedical applications. Microfluidic devices can be utilized to control the production of high-throughput cell-laden droplets. This paper demonstrates the effects of flow-focusing geometry on the droplet size, frequency of droplet generation, and number of cells per droplet. Orifice radius, orifice length, and nozzle-to-orifice distance can significantly influence the flow-field and manipulate droplet formation. This paper analyzes these geometry effects using a numerical front-tracking method for the three fluid phases. It is found that as the orifice radius increases, the drop size and the number of cells in the droplet increase. For a short orifice radius, increasing the orifice length results in the generation of smaller droplets at higher frequency and fewer cells per droplet. On the other hand, for a longer orifice, droplet production is invariant with respect to orifice length. It is also found that shorter distances between the nozzle and the orifice lead to a more controlled and uniform production of droplets. When the nozzle-to-orifice length is increased, the droplet formation becomes non-uniform and unpredictable. Probability charts are plotted with respect to the orifice length and orifice radius, which show that a greater than 50% probability of single cell encapsulation can be achieved consistently.
机译：细胞微囊化是一种在生物医学应用中保护活细胞的有前途的技术。微流体装置可用于控制高通量载有细胞的液滴的产生。本文演示了流动聚焦几何形状对液滴尺寸，液滴产生频率和每个液滴的细胞数的影响。孔半径，孔长度和喷嘴到孔的距离会显着影响流场并控制液滴的形成。本文使用数值前跟踪方法对这三个流体相分析了这些几何效应。已经发现，随着孔半径的增加，液滴的大小和液滴中的细胞数量也会增加。对于较短的孔口半径，增加孔口长度会导致以较高的频率生成较小的液滴，并且每个液滴的细胞数更少。另一方面，对于更长的孔，液滴的产生相对于孔长度是不变的。还发现喷嘴和孔口之间的距离越短，液滴的产生越可控且均匀。当喷嘴到孔的长度增加时，液滴的形成变得不均匀且不可预测。绘制了相对于孔口长度和孔口半径的概率图，表明大于 < mrow> 50 ％ 单个细胞封装的概率可以始终达到。

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