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首页> 美国卫生研究院文献>In Vivo >Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas
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Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas

机译：初步报告：常规腺瘤下非发育异常的腐败结肠隐窝中有多个增殖细胞簇

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Background: The finding was recently reported of clusters of colonic crypts lined with indigenous normal epithelium displaying irregular shapes underneath the adenomatous glands of conventional (tubular or villous) adenomas. These abnormal crypts were named non-dysplastic corrupted colonic crypts (NDCs). This study explored the characteristics of cell proliferation in NDCs present in a cohort of conventional adenomas. Materials and Methods: Sections from six conventional adenomas were challenged with the proliferation marker Ki-67 (MIB1). MIB+ proliferating clusters were regarded as those exhibiting two or more adjoining MIB+ cells. Results: A total of 46 (range=1-18) NDCs were found underneath the six conventional adenomas. Out of the 46 NDCs, two exhibited only one proliferative cluster/crypt, 14 NDCs two clusters/crypt, 14 three clusters/crypt and the remaining 16 NDCs more than four distinct clusters/crypt. Conclusion: This preliminary study showed, evidently for the first time, that multiple, apparently haphazardly distributed clusters of proliferating cells are present in NDCs. Since the Ki-67 proliferation marker only labels progenitor daughter cells generated by stem cells, each MIB+ cluster in each NDC must have been produced by a single stem cell. Consequently, individual NDCs may harbor several stem cells, a deduction that is in concert with recent studies showing that in the normal human colon, the number of stem cells per crypt is of the order of five to six, or about 5% of the cell population of a single crypt.
机译：背景：最近发现的发现是在传统（管状或绒毛状）腺瘤的腺瘤腺体下衬有正常正常上皮的结肠隐窝簇呈不规则形状。这些异常隐窝被称为非增生性破坏性结肠隐窝（NDC）。这项研究探索了在一组常规腺瘤中存在的NDC中细胞增殖的特征。材料和方法：用增殖标记Ki-67（MIB1）攻击来自六个常规腺瘤的切片。 MIB +增殖簇被认为是表现出两个或更多个相邻的MIB +细胞的簇。结果：在六个常规腺瘤下共发现46个NDC（范围= 18-18）。在46个NDC中，有两个仅展示了一个增殖簇/隐窝，有14个NDC展示了两个簇/隐窝，有14个三个簇/隐窝，其余16个NDC超过了四个不同的簇/隐窝。结论：这项初步研究显然是第一次，显然在NDC中存在着多个明显杂乱分布的增殖细胞簇。由于Ki-67增殖标记仅标记由干细胞产生的祖细胞，因此每个NDC中的每个MIB +簇必须由单个干细胞产生。因此，单个NDC可能包含几个干细胞，这一推论与最近的研究一致，即在正常人结肠中，每个隐窝的干细胞数量约为5到6个，约占细胞的5％。单个隐窝的数量。

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