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首页> 美国卫生研究院文献>Mediators of Inflammation >Levels of Salivary IFN-gamma TNF-Alfa and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus
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Levels of Salivary IFN-gamma TNF-Alfa and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus

机译：唾液中IFN-γTNF-Alfa和TNF Receptor-2的水平作为（侵蚀性）口腔扁平苔藓的预后指标

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To explore the feasibility of detecting salivary levels of IFN-γ, TNF-α, and sTNFR-2 from erosive oral lichen planus (ELP) patients for clinical application, 20 ELP patients were enrolled in the study as were 20 age-sex-matched controls. From all subjects, saliva level of the tested biomarkers was determined by ELISA. Salivary profiles were assessed in ELP patients by ELISA after being treated with prednisone. A significantly higher level of IFN-γ (P ≤ .01), TNF-α (P ≤ .0001), and sTNFR-2 (P ≤ .01) was detected in ELP patients before treatment than in controls. Following treatment, the salivary levels of IFN-γ (P ≤ .01), TNF-α (P ≤ .05), and sTNFR-2 (P ≤ .01) decreased significantly when compared to their pretreatment levels. This study demonstrated that salivary IFN-γ, TNF-α, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring.
机译：为了探讨从侵蚀性口腔扁平苔藓（ELP）患者中检测唾液中IFN-γ，TNF-α和sTNFR-2的临床可行性的可行性，本研究招募了20名ELP患者，其中20名年龄性别匹配。控件。对于所有受试者，通过ELISA确定测试的生物标志物的唾液水平。用强的松治疗后，通过ELISA评估ELP患者的唾液状况。治疗前在ELP患者中检测到的IFN-γ（P≤.01），TNF-α（P≤.0001）和sTNFR-2（P≤.01）水平明显高于对照组。与治疗前相比，治疗后唾液中的IFN-γ（P≤0.01），TNF-α（P≤0.05）和sTNFR-2（P≤0.01）显着降低。这项研究表明，在ELP患者中唾液中的IFN-γ，TNF-α和sTNFR-2可以检测到，并在泼尼松治疗后显着降低，这可能揭示了在诊断和监测中使用这些与疾病相关的生物标记物的可能性。

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