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首页> 美国卫生研究院文献>Human Vaccines Immunotherapeutics >Trials and tribulations of conducting interventional studies in urban slums of a developing country: Experiences from Kolkata India
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Trials and tribulations of conducting interventional studies in urban slums of a developing country: Experiences from Kolkata India

机译：在发展中国家的城市贫民区进行干预研究的试验和磨难：印度加尔各答的经验

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摘要

Experimental studies involving human subjects provide most internally valid evidences in epidemiological research due to their robust methodology. While conducting population-based interventional studies, to achieve external validity, inclusion of information from vulnerable groups like urban slum-dwellers of the developing world, in the epidemiological estimates is of paramount importance. The challenges faced while conducting 2 consecutive large-scale, community-based vaccine trials in urban slums of Kolkata, India are presented in this article. Interventions in these communities often get constrained by issues pertaining to human rights and benefits, socio-cultural factors, political environment, methodological shortcomings in addition to the challenges in ensuring community participation. While conducting these trials although we intermittently faced obstacles, by virtue of having a long term and robust surveillance system and developing a trusted relationship between the researchers, community leaders and residents we were able to come up with a commendable community participation which culminated into the success of the interventions. Bridging the gap between research and field operations by incorporating knowledge gathered from interventional studies and making strategies to improve health conditions of these informal settlers is a major unfulfilled agenda. We believe the lessons learnt during our research will help researchers while developing efficient interventions in similar setting.
机译：涉及人类受试者的实验研究由于其可靠的方法而在流行病学研究中提供了最内部有效的证据。在进行基于人群的干预研究时，为了实现外部有效性，将流行病学估计中包括发展中国家等城市贫民窟居民等弱势群体的信息包括在内是至关重要的。本文介绍了在印度加尔各答的城市贫民窟中连续进行两次基于社区的大规模疫苗试验时面临的挑战。除了确保社区参与方面的挑战外，对这些社区的干预通常受到与人权和利益，社会文化因素，政治环境，方法学缺陷有关的问题的束缚。在进行这些试验的过程中，尽管我们断断续续地遇到障碍，但由于拥有长期而强大的监视系统，并且在研究人员，社区领导者和居民之间建立了可信赖的关系，我们能够提出值得称赞的社区参与，并最终取得了成功的干预措施。通过整合从干预研究中收集到的知识并制定改善这些非正式定居者健康状况的策略来弥合研究与现场操作之间的鸿沟是一个主要的未完成议程。我们相信，在研究过程中获得的经验教训将有助于研究人员在类似环境中开发有效的干预措施。

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