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首页> 美国卫生研究院文献>Gut >Diagnostic value of serum primary bile acids in detecting bile acid malabsorption.
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Diagnostic value of serum primary bile acids in detecting bile acid malabsorption.

机译：血清初级胆汁酸对检测胆汁酸吸收不良的诊断价值。

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摘要

Serum cholic and chenodeoxycholic acid conjugates were measured in fasting conditions and after meals in 14 patients with bile acid malabsorption due to ileal resection. Mean serum fasting levels of both primary bile acids did not differ from the controls. After meals, serum cholic acid peaks were lower in patients with ileal resection than in control subjects (p less than 0.001), while chenodeoxycholic acid peaks were reduced in colectomised patients (p less than 0.01). In the sera from patients with ileal resection, the glycine/glycine + taurine ratio for cholic and chenodeoxycholic acid increased (p less than 0.001) from morning to evening, and glycine/glycine + taurine ratio for chenodeoxycholic acid was significantly (p less than 0.01) different from the controls in the sera collected in the evening. The results are consistent with the concept of a better intestinal conservation of chenyl, mainly of the glycine conjugated from, than of cholylconjugates, in patients with ileal resection; this is probably because of passive absorption in the intestine. The postprandial peaks of serum cholic acid conjugates may therefore be regarded as a test of ileal dysfunction, while peaks of chenodeoxycholic acid conjugates suggest colonic impairment.
机译：在空腹条件下和餐后对14例因回肠切除导致胆汁酸吸收不良的患者的血清胆酸和鹅去氧胆酸结合物进行了测定。两种初级胆汁酸的平均血清禁食水平与对照组无差异。进餐后，回肠切除术患者的血清胆酸峰值低于对照组（p小于0.001），而电切术患者的鹅去氧胆酸峰值降低（p小于0.01）。回肠切除患者的血清中，早，晚胆汁和鹅去氧胆酸的甘氨酸/甘氨酸+牛磺酸比值升高（p小于0.001），鹅去氧胆酸的甘氨酸/甘氨酸+牛磺酸的比值显着（p小于0.01）。 ）与晚上收集的血清中的对照不同。该结果与回肠切除术中的更好的肠基保护性思想相吻合，主要是由胆碱结合的甘氨酸比胆碱结合的肠。这可能是由于肠道中的被动吸收。餐后血清胆酸结合物的峰可被认为是回肠功能障碍的测试，而鹅去氧胆酸结合物的峰则表明结肠受损。

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