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Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations

机译：抑制转化生长因子β信号传导使中性蛋白酶引起的胰腺炎中止并消除了高浓度的中性蛋白酶

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BackgroundTransforming growth factors βs (TGF‐βs) are implicated in pancreatic tissue repair but their role in acute pancreatitis is not known. To determine whether endogenous TGF‐βs modulate the course of caerulein induced acute pancreatitis, caerulein was administered to wild‐type (FVB−/−) and transgenic mice that are heterozygous (FVB+/−) for expression of a dominant negative type II TGF‐β receptor.

机译：背景转化生长因子βs（TGF-βs）与胰腺组织修复有关，但在急性胰腺炎中的作用尚不清楚。为了确定内源性TGF-β是否调节了由caerulein诱导的急性胰腺炎的病程，将caerulein应用于野生型（FVB-/-）和杂合子（FVB +/-）的转基因小鼠，以表达显性阴性II型TGF- β受体。

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期刊名称 Gut
作者
Stefan Wildi; Jörg Kleeff; Julia Mayerle; Arthur Zimmermann; Erwin P Böttinger; Lalage Wakefield; Markus W Büchler; Helmut Friess; Murray Korc;
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作者单位

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年(卷),期 2007(56),5
年度 2007
页码 685–692
总页数 8
原文格式 PDF
正文语种
中图分类肠道病毒与肝炎病毒;肝及胆疾病;肠疾病;
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专利

1. Role of Kinase Epidermal Growth Factor Receptor and SRC in the Caerulein-Induced Acute Pancreatitis in Mice [J] . Huang Yongming, Xia Weiliang, Lu Ming, Pancreas . 2015,第1期

机译：激酶表皮生长因子受体和SRC在Caerulein诱导的小鼠急性胰腺炎中的作用
2. Epidermal growth factor accelerates pancreatic recovery after caerulein-induced pancreatitis. [J] . Dembinski A, Warzecha Z, Konturek PC, European Journal of Pharmacology: An International Journal . 2000,第1期

机译：表皮生长因子加速了由轻油霉素诱导的胰腺炎后的胰腺恢复。
3. Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data [J] . Qi Dachuan, Wu Bo, Tong Danian, Molecular medicine reports . 2015,第2aPta2期

机译：通过表达谱数据鉴定轻油霉素诱导的胰腺炎中的关键转录因子
4. Green Tea Polyphenol Extract Ameliorates Pancreatic Injury in Caerulein-induced Murine Acute Pancreatitis [C] . T. Genovese, BI. Babu, E. Mazzon, Conference on Shock . 2008

机译：绿茶多酚提取物改善了Caerulein诱导的小鼠急性胰腺炎的胰腺损伤
5. Transforming growth factor-beta1 activation and transforming growth factor-beta receptor 2 expression levels in the regulation of the TGF-beta signaling pathway. [D] . Rojas, Andres. 2008

机译：在调节TGF-beta信号通路中转化生长因子-beta1激活和转化生长因子-beta受体2的表达水平。
6. TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model [O] . Chaohao Huang, Shengchuan Chen, Tan Zhang, -1

机译：TLR3配体PolyI：C通过Caerulein诱导的胰腺炎小鼠模型通过干扰素-β/干扰素-α/β受体信号传导途径预防急性胰腺炎
7. Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations [O] . Wildi, Stefan, Kleeff, Jörg, Mayerle, Julia, 2007

机译：抑制转化生长因子β信号传导使中性蛋白酶引起的胰腺炎中止，并消除了高浓度的中性蛋白酶

Suppression of transforming growth factor β signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations

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