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首页> 美国卫生研究院文献>Health Promotion Perspectives >Lifestyle Modification through Dietary Intervention: Health Promotion of Patients with Non-Alcoholic Fatty Liver Disease
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Lifestyle Modification through Dietary Intervention: Health Promotion of Patients with Non-Alcoholic Fatty Liver Disease

机译：通过饮食干预改变生活方式：非酒精性脂肪肝患者的健康促进

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>Background: Prevalence of non-alcoholic fatty liver disease (NAFLD) is more common worldwide and no certain treatment apart from lifestyle modification has been established yet. Available data consistently show that energy intake is significantly higher in patients with NAFLD than in individuals with no evidence of fatty liver. Changing nutritional behaviors seems to be the primary approach for treatment, simultaneously addressing all the clinical and biochemical defects. This study was aimed to examine the effects of two different composition of low energy diet (diet I vs. diet II) on non-alcoholic fatty liver disease patients. >Methods: In this double-blind randomized controlled trial, 44 ultrasonography-proven overweight non-alcoholic fatty liver disease patients were divided into two groups and received two low-energy diets (-500 kcal less than energy requirement individually) inc. diet I (Carbohydrate: Fat: Protein: 55:25:20) and diet II (Carbohydrate: Fat: Protein: 40:40:20) for six weeks. Anthropometric and biochemical measures as well as liver enzymes were assessed after 12 hours fasting. >Results: After diet I and diet II, weight decreased significantly (%1.82 and %2.45, respectively). Liver enzymes and echogenicity decreased significantly by both diet I and diet II. Mean of triglyceride concentration decreased (%18.09) after diet II (P=0.023), while there was no significant change after diet I. Significant correlations were found between changes in aspartate aminotransferase with triglyceride and LDL-C diet I. >Conclusion: Low energy diets can decrease liver enzymes regardless of their composition, while diet II seems to be more effective than diet I in reduction of weight and triglyceride level.
机译：>背景：非酒精性脂肪肝疾病（NAFLD）的流行在全世界范围内更为普遍，除了改变生活方式之外，还没有确定的治疗方法。现有数据一致表明，NAFLD患者的能量摄入量明显高于无脂肪肝证据的个体。改变营养行为似乎是治疗的主要方法，同时解决所有临床和生化缺陷。这项研究旨在检查两种低能量饮食组成（饮食I与饮食II）对非酒精性脂肪肝患者的影响。 >方法：在这项双盲随机对照试验中，将44例经超声检查证实超重的非酒精性脂肪肝患者分为两组，并接受两种低能量饮食（比能量需求少-500 kcal）个别地）公司。饮食I（碳水化合物：脂肪：蛋白质：55：25：20）和饮食II（碳水化合物：脂肪：蛋白质：40：40：20）持续六周。禁食12小时后评估人体和生化指标以及肝酶。 >结果：饮食I和饮食II后，体重显着下降（分别为％1.82和％2.45）。饮食I和饮食II均显着降低了肝脏的酶和回声。饮食II后平均甘油三酯浓度降低（％18.09）（P = 0.023），而饮食I后没有显着变化。发现甘油三酸酯和LDL-C饮食I的天冬氨酸转氨酶变化之间存在显着相关性。>结论：低能量饮食可以减少肝脏酶，无论其成分如何，而饮食II在减轻体重和降低甘油三酸酯水平方面似乎比饮食I更有效。

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