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Randomized Controlled Trial: Targeted Neck Cooling in the Treatment of the Migraine Patient

机译:随机对照试验:偏头痛患者的靶向颈降温治疗

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摘要

Cold therapy has long been the number one self-care treatment employed for migraine without aura and the second most common for migraine with aura, yet its mechanism remains elusive. In this study, a mechanism by which this time-tested therapy works is proposed (by cooling the blood passing through intracranial vessels) in an attempt to further elucidate its beneficial effects. The study is designed as a randomized, controlled, crossover clinical trial utilizing an adjustable wrap containing two freezable ice packs targeting the carotid arteries at the neck, where they come close to the skin surface. Fifty-five participants successfully completed the study. Pain at onset, as recorded on a visual analog scale, was similar between the two treatment arms. Maximum pain reduction was observed at the 30 minute time point with a 31.8% ± 15.2% decrease in pain in the treatment arm compared to a 31.5% ± 20.0% increase in pain at the same time interval in the control arm. These findings confirm the application of a frozen neck wrap at onset of migraine headache targeting the carotid arteries at the neck significantly reduced recorded pain in participants with migraine headaches (P<.001).
机译:长期以来,冷疗法一直是无先兆偏头痛的第一位自我护理治疗方法,而有先兆偏头痛的第二种最常见的自我治疗方法,但其作用机制仍然难以捉摸。在这项研究中,提出了一种经过时间考验的治疗工作的机制(通过冷却流经颅内血管的血液),以试图进一步阐明其有益作用。该研究被设计为一项随机,对照,交叉临床试验,使用可调节包裹剂包裹,该包裹剂包含两个可冷冻的冰袋,这些冰袋对准颈部的颈动脉,靠近皮肤表面。 55名参与者成功完成了研究。如以视觉模拟量表记录的那样,两个治疗组之间的疼痛相似。在30分钟的时间点观察到最大程度的疼痛减轻,治疗组的疼痛减少了31.8%±15.2%,而对照组的相同时间间隔的疼痛增加了31.5%±20.0%。这些发现证实,在偏头痛发作时以颈部颈动脉为目标的冷冻颈部包裹物的应用可显着减少偏头痛参与者的记录疼痛(P <.001)。

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