首页> 美国卫生研究院文献>Haematologica >Pre-morbid human T-lymphotropic virus type I proviral load rather than percentage of abnormal lymphocytes is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma
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Pre-morbid human T-lymphotropic virus type I proviral load rather than percentage of abnormal lymphocytes is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma

机译:患病前的人类T型淋巴病毒I型前病毒载量而不是异常淋巴细胞的百分率与侵袭性成人T细胞白血病/淋巴瘤的风险增加相关

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摘要

Out of 153 newly referred human T-lymphotropic virus type I infected patients, 42 (27%) had 5% or more abnormal lymphocytes, consistent with the diagnosis of smoldering adult T-cell leukemia/lymphoma. The abnormal lymphocyte percentage was higher in patients with human T-lymphotropic virus type I associated inflammatory disease compared with asymptomatic carriers (P=0.006). Over 4.5 years median follow up, 4 patients, all with 10 or more human T-lymphotropic virus type I DNA copies/100 peripheral blood mononuclear cells at presentation, but only one with 5% or more abnormal lymphocytes at presentation, developed adult T-cell leukemia/lymphoma. Thus, high pre-morbid human T-lymphotropic virus type I proviral load, rather than fulfilment of the classification criteria for smoldering adult T-cell leukemia/lymphoma, was associated with an increased risk of developing aggressive adult T-cell leukemia/lymphoma.
机译:在153名新转诊的人类T型淋巴病毒I型感染患者中,有42名(27%)的淋巴细胞异常率为5%或以上,这与阴燃的成人T细胞白血病/淋巴瘤的诊断相符。与无症状携带者相比,人类T型淋巴病毒I型炎性疾病患者的异常淋巴细胞百分比更高(P = 0.006)。经过4.5年的中位随访,有4例患者均出现了成人T-病,这些患者均具有10或更多的人I型T淋巴细胞病毒I型DNA拷贝/ 100个外周血单个核细胞,但只有1个具有5%或以上异常淋巴细胞的患者。细胞白血病/淋巴瘤。因此,高发病率的人类I型淋巴病毒I型前病毒载量高,而不是满足闷烧成年T细胞白血病/淋巴瘤的分类标准,与发展成年成人T细胞白血病/淋巴瘤的风险增加有关。

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