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Ontogenetic Survey of Histone Modifications in an Annelid

机译：Annlid中组蛋白修饰的本体遗传学调查

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摘要

Histone modifications are widely recognized for their fundamental importance in regulating gene expression in embryonic development in a wide range of eukaryotes, but they have received relatively little attention in the development of marine invertebrates. We surveyed histone modifications throughout the development of a marine annelid, Polydora cornuta, to determine if modifications could be detected immunohistochemically and if there were characteristic changes in modifications throughout ontogeny (surveyed at representative stages from oocyte to adult). We found a common time of onset for three histone modifications in early cleavage (H3K14ac, H3K9me, and H3K4me2), some differences in the distribution of modifications among germ layers, differences in epifluorescence intensity in specific cell lineages suggesting that hyperacetylation (H3K14ac) and hypermethylation (H3K9me) occur during differentiation, and an overall decrease in the distribution of modifications from larvae to adults. Although preliminary, these results suggest that histone modifications are involved in activating early development and differentiation in a marine invertebrate.
机译：组蛋白修饰因其在调节各种真核生物胚胎发育中的基因表达中的根本重要性而被广泛认可，但它们在海洋无脊椎动物的发育中受到的关注相对较少。我们调查了整个海洋肘类动​​物，Polydora cornuta的整个过程中的组蛋白修饰，以确定修饰是否可以通过免疫组织化学检测到，以及修饰在整个个体发育中是否存在特征性变化（在从卵母细胞到成年的代表性阶段进行调查）。我们发现了在早期裂解中发生三个组蛋白修饰的常见时间（H3K14ac，H3K9me和H3K4me2），胚芽层中修饰分布的差异，特定细胞谱系中的表观荧光强度的差异表明超乙酰化（H3K14ac）和超甲基化（H3K9me）在分化过程中发生，并且从幼虫到成虫的修饰分布总体上减少。尽管是初步的，但这些结果表明，组蛋白修饰与激活海洋无脊椎动物的早期发育和分化有关。

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