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Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol a putative probe drug of MDR1 and other membrane transporters

机译：他尼洛尔药代动力学的遗传力低：关于他尼洛尔MDR1的推定探针药物和其他膜转运蛋白的药代动力学的遗传遗传学双重研究

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摘要

BackgroundEfflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of talinolol as a putative probe drug for MDR1 and possibly other membrane transporters.

机译：背景外排转运蛋白如MDR1和MRP2可能调节所有药物中约50％的药代动力学。目前尚不清楚重要药物膜转运蛋白（如MDR1或MRP2）的活性变化有多少是由遗传或环境因素决定的。在这项研究中，我们评估了替尼洛尔作为MDR1和其他膜转运蛋白的推定探针药物的药代动力学的遗传力。

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期刊名称 Genome Medicine
作者
Johannes Matthaei; Mladen V. Tzvetkov; Valerie Gal; Cordula Sachse-Seeboth; Daniel Sehrt; Jakob B. Hjelmborg; Ute Hofmann; Matthias Schwab; Reinhold Kerb; Jürgen Brockmöller;
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作者单位

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年(卷),期 2016(8),-1
年度 2016
页码 119
总页数 12
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
Talinolol MDR1 P-glycoprotein ABCB1 MDR5 MRP2 ABCC2 BCRP Heritability Twin study;

机译：他林洛尔;MDR1;P-糖蛋白;ABCB1;MDR5;MRP2;ABCC2;BCRP;遗传力;双生子研究;

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专利

1. Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions [J] . MA Nguyen, P. Staubach, S. Wolffram, European journal of pharmaceutical sciences . 2014,第Null期

机译：槲皮素的单剂量和短期给药对他尼洛尔在人体中药代动力学的影响-对评估转运蛋白介导的类黄酮-药物相互作用的意义
2. Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions [J] . MA Nguyen, P. Staubach, S. Wolffram, European journal of pharmaceutical sciences . 2014,第Null期

机译：单剂量和短期施用槲皮素对人类对人类药代动力学的影响 - 对转运介导的黄酮类药物相互作用评价的影响
3. The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. [J] . Siegmund W, Ludwig K, Giessmann T, Clinical Pharmacology and Therapeutics . 2002,第5期

机译：人类MDR1基因型对十二指肠P-糖蛋白表达和探针药物塔利洛尔的影响。
4. Heritability of White Matter Fiber Tract Shapes:A HARDI Study of 198 Twins [C] . Yan Jin, Yonggang Shi, Shantanu H. Joshi, Multimodal Brain Image Analysis . 2011

机译：白质纤维束形状的遗传性：对198个双胞胎的HARDI研究
5. Identification of membrane transporters to facilitate intranasal drug delivery using tissue-based and pharmacokinetic approaches. [D] . Zhang, Hefei. 2009

机译：使用基于组织和药代动力学的方法鉴定膜转运蛋白以利于鼻内药物输送。
6. Measuring the Overall Genetic Component of Nevirapine Pharmacokinetics and the Role of Selected Polymorphisms: Towards Addressing the Missing Heritability in Pharmacogenetic Phenotypes? [O] . Janine E. Micheli, Leslie W. Chinn, Sarah B. Shugarts, -1

机译：测量Nevirapine药代动力学的整体遗传成分和所选多态性的作用：试图解决药物遗传表型的遗传性缺失？
7. Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters [O] . Johannes Matthaei, Mladen V. Tzvetkov, Valerie Gal, 2016

机译：他尼洛尔药代动力学的遗传性较低：关于他尼洛尔，MDR1和其他膜转运蛋白的推定探针药物的药代动力学遗传性的双药理研究

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol a putative probe drug of MDR1 and other membrane transporters

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