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首页> 美国卫生研究院文献>Genetics >Induced Rates of Mitotic Crossing over and Possible Mitotic Gene Conversion per Wing Anlage Cell in Drosophila Melanogaster by X Rays and Fission Neutrons
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Induced Rates of Mitotic Crossing over and Possible Mitotic Gene Conversion per Wing Anlage Cell in Drosophila Melanogaster by X Rays and Fission Neutrons

机译：X射线和裂变中子在果蝇中诱导的有丝分裂穿越速率和可能的每个翼成活细胞的有丝分裂基因转化

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摘要

As a model for chromosome aberrations, radiation-induced mitotic recombination of mwh and flr genes in Drosophila melanogaster strain (mwh +/+ flr) was quantitatively studied. Fission neutrons were five to six times more effective than X rays per unit dose in producing either crossover-mwh/flr twins and mwh singles--or flr singles, indicating that common processes are involved in the production of crossover and flr singles. The X-ray-induced rate/wing anlage cell/Gy for flr singles was 1 X 10(-5), whereas that of crossover was 2 X 10(-4); the former and the latter rate are of the same order of magnitude as those of gene conversion and crossover in yeast, respectively. Thus, we conclude that proximal-marker ``flr'' singles induced in the transheterozygote are gene convertants. Using the model based on yeast that recombination events result from repair of double-strand breaks or gaps, we propose that mitotic recombination in the fly is a secondary result of recombinational DNA repair. Evidence for recombinational misrepair in the fly is given. The relative ratio of radiation-induced mitotic crossover to spontaneous meiotic crossover is one order of magnitude higher in the fly than in yeast and humans.
机译：作为染色体畸变的模型，定量研究了果蝇（mwh + / + flr）菌株中辐射诱导的mwh和flr基因的有丝分裂重组。裂变中子在产生交叉-mwh / flr双胞胎和mwh单-或flr单胞中的效率比每单位剂量X射线高五到六倍，这表明生产交叉和flr单胞涉及到共同的过程。 X射线诱导的flr单打的速率/双侧翼细胞/ Gy为1 X 10（-5），交叉的为2 X 10（-4）；前者和后者的速率分别与酵母中的基因转化和交叉速率相同。因此，我们得出的结论是，在杂合子中诱导的近端标记``flr''是基因转化体。使用基于酵母的模型，其中重组事件是由双链断裂或缺口的修复引起的，我们建议果蝇中的有丝分裂重组是重组DNA修复的次要结果。给出了飞行中重组失修的证据。辐射诱导的有丝分裂交换与自发性减数分裂交换的相对比率在飞行中比在酵母和人类中高一个数量级。

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