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No time to lose: workshop on circadian rhythms and metabolic disease

机译：刻不容缓：昼夜节律和代谢疾病研讨会

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The objective of the workshop was to gain a better understanding of the link between circadian rhythms and human health and disease. The impacts of circadian rhythms on metabolic gene regulation, as well as the effect of nutrient uptake and balance on the molecular components of the clock, were discussed. Topics included the neural circuitry underlying the central clock; the effect of the environment and diet on the central clock as well as peripheral, tissue-specific clocks; and the transcriptional, post-transcriptional, and post-translational (e.g., epigenomic) mechanisms through which these signals are transduced. Evidence presented during the meeting demonstrated that circadian rhythms and metabolism are intricately linked, and that disruption in these rhythms have profound consequences—many times leading to metabolic disease. The mechanisms by which circadian rhythms are maintained and the cross-talk with metabolic signaling are just beginning to be elucidated. However, the interactions between these fields and the knowledge learned will clearly have a profound impact on our understanding of metabolic disease and lead to novel therapeutic approaches in the future
机译：研讨会的目的是更好地了解昼夜节律与人类健康和疾病之间的联系。讨论了昼夜节律对代谢基因调控的影响，以及养分吸收和平衡对钟表分子组成的影响。主题包括中央时钟背后的神经电路。环境和饮食对中央时钟以及外围组织专用时钟的影响；以及通过这些信号转导的转录，转录后和翻译后（例如表观基因组）机制。会议期间提供的证据表明，昼夜节律和新陈代谢之间有着千丝万缕的联系，这些节律的破坏会产生深远的后果，很多时候会导致新陈代谢疾病。维持昼夜节律的机制以及与代谢信号传导的串扰才刚刚被阐明。然而，这些领域与所学知识之间的相互作用显然将对我们对代谢疾病的理解产生深远影响，并在未来导致新的治疗方法

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