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首页> 美国卫生研究院文献>Medical Gas Research >Effect of different doses of intrathecal dexmedetomidine on hemodynamic parameters and block characteristics after ropivacaine spinal anesthesia in lower-limb orthopedic surgery: a randomized clinical trial
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Effect of different doses of intrathecal dexmedetomidine on hemodynamic parameters and block characteristics after ropivacaine spinal anesthesia in lower-limb orthopedic surgery: a randomized clinical trial

机译：下肢整形外科手术中不同剂量鞘内注射右美托咪定对罗哌卡因脊髓麻醉后血液动力学参数和阻滞特性的影响：一项随机临床试验

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The study aims to compare the efficacy of different doses of intrathecal dexmedetomidine on hemodynamic parameters and block characteristics after ropivacaine spinal anesthesia in lower-limb orthopedic surgery. In a double-blind trial, 90 patients undergoing spinal anesthesia for lower-limb orthopedic surgery were included and then randomly assigned to three groups; dexmedetomidine 5 μg/kg, dexmedetomidine 10 μg/kg and placebo. Blood pressure, heart rate, and oxygen saturation were recorded in the three groups at the first 15 minutes and then every 15 to 180 minutes at recovery by a resident anesthesiologist, as well as sensory-motor block onset. The visual analog scale scores for the assessment of pain were recorded at recovery, and 2, 4, 6, and 12 hours postoperatively and the data were analyzed by Stata software. The onset and time to achieve sensory block to ≥ T8 were faster in the 10 μg/kg dexmedetomidine group than the other groups (P = 0.001). The Bromage score was higher in the 10 μg/kg dexmedetomidine group (P = 0.0001) with lower pain score as compared with the 5 μg/kg dexmedetomidine and placebo groups (P = 0.0001). Therefore, an increase in dexmedetomidine hastens the onset of sensory-motor block but not causes side effects. This study was approved by the Ethical Committee of Arak University of Medical Sciences in 2017 (Ethical Code: IR.ARAKMU.REC.1396.37), and the trail was registered and approved by the Iranian Registry of Clinical Trials in 2017 (IRCT No. IRCT2017070614056N12).
机译：该研究旨在比较在下肢整形外科手术中不同剂量鞘内注射右美托咪定对罗哌卡因脊髓麻醉后血液动力学参数和阻滞特性的疗效。在一项双盲试验中，纳入了90例接受下肢骨科手术的脊柱麻醉的患者，然后随机分为三组：右美托咪定5μg/ kg，右美托咪定10μg/ kg和安慰剂。在开始的15分钟内，然后在住院麻醉师恢复时每15到180分钟记录三组的血压，心率和血氧饱和度，以及感觉运动阻滞发作。在恢复时，术后2、4、6和12小时记录用于评估疼痛的视觉模拟量表评分，并通过Stata软件分析数据。在10μg/ kg右美托咪定组中，达到≥T8的感觉阻滞的发作和时间要比其他组快（P = 0.001）。与5μg/ kg右美托咪定和安慰剂组相比，10μg/ kg右美托咪定组的Bromage评分较高（P = 0.0001），疼痛评分较低。因此，右美托咪定的增加会加速感觉运动阻滞的发作，但不会引起副作用。该研究于2017年获得阿拉克医科大学伦理委员会的批准（道德规范：IR.ARAKMU.REC.1396.37），该试验已于2017年由伊朗临床试验注册机构注册并批准（IRCT号IRCT2017070614056N12 ）。

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