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首页> 美国卫生研究院文献>Medical Gas Research >Effects of normobaric versus hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices
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Effects of normobaric versus hyperbaric oxygen on cell injury induced by oxygen and glucose deprivation in acute brain slices

机译：常压和高压氧对急性脑切片缺氧和缺糖所致细胞损伤的影响

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摘要

Normobaric oxygen (NBO) and hyperbaric oxygen (HBO) are emerging as a possible co-treatment of acute ischemic stroke. Both have been shown to reduce infarct volume, to improve neurologic outcome, to promote endogenous tissue plasminogen activator-induced thrombolysis and cerebral blood flow, and to improve tissue oxygenation through oxygen diffusion in the ischemic areas, thereby questioning the interest of HBO compared to NBO. In the present study, in order to investigate and compare the oxygen diffusion effects of NBO and HBO on acute ischemic stroke independently of their effects at the vascular level, we used acute brain slices exposed to oxygen and glucose deprivation, an ex vivo model of brain ischemia that allows investigating the acute effects of NBO (partial pressure of oxygen (pO2) = 1 atmospheres absolute (ATA) = 0.1 MPa) and HBO (pO2 = 2.5 ATA = 0.25 MPa) through tissue oxygenation on ischemia-induced cell injury as measured by the release of lactate dehydrogenase. We found that HBO, but not NBO, reduced oxygen and glucose deprivation-induced cell injury, indicating that passive tissue oxygenation (i.e. without vascular support) of the brain parenchyma requires oxygen partial pressure higher than 1 ATA.
机译：正常氧（NBO）和高压氧（HBO）可能作为急性缺血性中风的一种可能的联合治疗方法出现。已显示两者均能减少梗塞体积，改善神经系统结局，促进内源性纤溶酶原激活物诱导的血栓溶解和脑血流量，以及通过氧在缺血区域的扩散而改善组织氧合，因此质疑HBO与NBO的兴趣。在本研究中，为了研究和比较NBO和HBO对急性缺血性中风的氧扩散作用，而与它们在血管水平上的作用无关，我们使用了暴露于缺氧和缺糖的急性脑片，这是一种体外脑模型缺血可通过组织充氧研究NBO（氧分压（pO2）= 1大气压绝对（ATA）= 0.1 MPa）和HBO（pO2 = 2.5 ATA = 0.25 MPa）对局部缺血诱导的细胞损伤的急性影响通过释放乳酸脱氢酶。我们发现HBO而非NBO减少了氧气和葡萄糖剥夺引起的细胞损伤，表明脑实质的被动组织氧合（即无血管支持）需要的氧分压高于1 ATA。

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